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Afti Aftiphilin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41744, updated on 9-Dec-2024

Summary

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Official Symbol
Aftiprovided by FlyBase
Official Full Name
Aftiphilinprovided by FlyBase
Primary source
FLYBASE:FBgn0038223
Locus tag
Dmel_CG8538
See related
AllianceGenome:FB:FBgn0038223
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8538; dAfti; Dmel\CG8538
Summary
Enables AP-1 adaptor complex binding activity and clathrin adaptor activity. Involved in compound eye photoreceptor development and intracellular transport. Located in trans-Golgi network membrane. Orthologous to human AFTPH (aftiphilin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Afti in Genome Data Viewer
Location:
88B3-88B4; 3-55 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14320191..14326689, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10145913..10152411, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Corazonin Neighboring gene SET domain containing 8 Neighboring gene ATP synthase, subunit E Neighboring gene spindle B Neighboring gene NK7.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster. Kametaka S, et al. J Cell Sci, 2012 Feb 1. PMID 22389401
  2. Prevalence of off-target effects in Drosophila RNA interference screens. Ma Y, et al. Nature, 2006 Sep 21. PMID 16964239
  3. A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress. Dalton HM, et al. PLoS Genet, 2022 Sep. PMID 36166480, Free PMC Article
  4. Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster. Dunn JG, et al. Elife, 2013 Dec 3. PMID 24302569, Free PMC Article
  5. Identification of genes that promote or inhibit olfactory memory formation in Drosophila. Walkinshaw E, et al. Genetics, 2015 Apr. PMID 25644700, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CG8538p, an uncharacterized Drosophila protein, shares significant structural and functional characteristics with Aftiphilin, a mammalian AP-1 accessory protein.
    Title: AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables AP-1 adaptor complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables clathrin adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye photoreceptor development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of AP-1 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aftiphilin
Names
Afti-PB
Afti-PC
Afti-PD
Afti-PE
CG8538-PB
CG8538-PC
CG8538-PD
CG8538-PE
dAftiphilin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    14320191..14326689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260173.2 → NP_001247102.1  aftiphilin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247102.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86P42, Q9VFK5
    Conserved Domains (1) summary
    pfam15045
    Location:459 → 516
    Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking

  2. NM_001260172.2 → NP_001247101.1  aftiphilin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247101.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86P42, Q9VFK5
    Conserved Domains (1) summary
    pfam15045
    Location:459 → 516
    Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking

  3. NM_001370051.1 → NP_001356916.1  aftiphilin, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4D6K2J4
    Conserved Domains (1) summary
    pfam15045
    Location:462 → 516
    Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking

  4. NM_142098.4 → NP_650355.2  aftiphilin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650355.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86P42, Q9VFK5
    Conserved Domains (1) summary
    pfam15045
    Location:459 → 516
    Clathrin_bdg; Clathrin-binding box of Aftiphilin, vesicle trafficking
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A4D6K2J4 A0A4D6K2J4
Q9VFK5 Q9VFK5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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