Crz Corazonin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Crzprovided by FlyBase
Official Full Name: Corazoninprovided by FlyBase
Primary source: FLYBASE:FBgn0013767
Locus tag: Dmel_CG3302
See related: AllianceGenome:FB:FBgn0013767
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3302; cor; COR; Cora; CORZ; crz; CRZ; Dm-Crz; Dmel\CG3302; Drm-COR
Summary: Enables corazonin receptor binding activity. Involved in acetaldehyde metabolic process; neuropeptide signaling pathway; and response to ethanol. Acts upstream of with a positive effect on courtship behavior. Located in extracellular space. Is expressed in several structures, including adult brain; adult optic lobe; adult pars lateralis; neuromere; and neurosecretory neurons. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 88B3-88B3; 3-55 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (14314854..14315716)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (10140576..10141438)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GnRH-Related Neurohormones in the Fruit Fly Drosophila melanogaster.
Title: GnRH-Related Neurohormones in the Fruit Fly Drosophila melanogaster.
We find two STIM-regulated peptides, Corazonin and short Neuropeptide F, to be required for NR larvae to complete development. Further, a set of secretory DLP (Dorso lateral peptidergic) neurons which co-express both peptides was identified
Title: ER-Ca2+ sensor STIM regulates neuropeptides required for development under nutrient restriction in Drosophila.
Loss of Atg16 delays the alcohol-induced sedation response via regulation of Corazonin neuropeptide production in Drosophila.
Title: Loss of Atg16 delays the alcohol-induced sedation response via regulation of Corazonin neuropeptide production in Drosophila.
Results show that the Crz action triggers transcriptional changes in the adipocytes that include stress genes and one gene involved in metabolism.
Title: Systemic corazonin signalling modulates stress responses and metabolism in Drosophila.
Findings indicate that short neuropeptide F (sNPF) and corazonin (CRZ) co-released from a small set of neurons regulate insulin-producing cells (IPCs) stress resistance and metabolism.
Title: Identified peptidergic neurons in the Drosophila brain regulate insulin-producing cells, stress responses and metabolism by coexpressed short neuropeptide F and corazonin.
CrzR-associated signaling pathway is critical for ethanol detoxification via Crz-dependent regulation of ALDH activity and Crz-independent transcriptional regulation of ADH.
Title: Regulation of ethanol-related behavior and ethanol metabolism by the Corazonin neurons and Corazonin receptor in Drosophila melanogaster.
The work presented here identifies two genes, apt and crz, which mediate the fly's sensitivity to ethanol-induced sedation.
Title: A small group of neurosecretory cells expressing the transcriptional regulator apontic and the neuropeptide corazonin mediate ethanol sedation in Drosophila.
Data show that altered corazonin neuron physiology leads to fundamental differences in locomotor activity, and these effects were also sex-dependent.
Title: Corazonin neurons function in sexually dimorphic circuitry that shape behavioral responses to stress in Drosophila.
The tissue-, stage-, and sex-specific expression of Crz and the association of Crz with the function of the retrocerebral complex suggest diverse roles for this neuropeptide in Drosophila.
Title: Developmental regulation and functions of the expression of the neuropeptide corazonin in Drosophila melanogaster.
We show that the 504-bp 5' upstream sequence is the shortest promoter directing reporter activities in all Drosophila Corazonin neurons.
Title: Spatial regulation of Corazonin neuropeptide expression requires multiple cis-acting elements in Drosophila melanogaster.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables corazonin receptor binding	IEA Inferred from Electronic Annotation more info
enables corazonin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables neuropeptide hormone activity	ISS Inferred from Sequence or Structural Similarity more info
enables neuropeptide hormone activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in acetaldehyde metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuropeptide signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of heart contraction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of heart contraction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed