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ems empty spiracles [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41697, updated on 9-Dec-2024

Summary

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Official Symbol
emsprovided by FlyBase
Official Full Name
empty spiraclesprovided by FlyBase
Primary source
FLYBASE:FBgn0000576
Locus tag
Dmel_CG2988
See related
AllianceGenome:FB:FBgn0000576
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ant; CG2988; Dmel\CG2988; E4; Ems; EMS; W13
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic development via the syncytial blastoderm; nervous system development; and spiracle morphogenesis, open tracheal system. Located in nucleus. Is expressed in several structures, including anterior-posterior subdivision of organism; epithelium; head epidermis primordium; neuroblasts; and neuromere. Human ortholog(s) of this gene implicated in colorectal cancer and stomach cancer. Orthologous to human EMX2 (empty spiracles homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See ems in Genome Data Viewer
Location:
88A2-88A2; 3-54 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13901853..13904620)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9727575..9730342)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46239 Neighboring gene E5 Neighboring gene Arginine methyltransferase 9 Neighboring gene Arginine methyltransferase 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A developmental atlas of male terminalia across twelve species of Drosophila. Urum A, et al. Front Cell Dev Biol, 2024. PMID 38487271, Free PMC Article
  2. Orthodenticle is required for the development of olfactory projection neurons and local interneurons in Drosophila. Sen S, et al. Biol Open, 2014 Jul 4. PMID 24996925, Free PMC Article
  3. Conserved roles of ems/Emx and otd/Otx genes in olfactory and visual system development in Drosophila and mouse. Sen S, et al. Open Biol, 2013 May 1. PMID 23635521, Free PMC Article
  4. Sequential addition of neuronal stem cell temporal cohorts generates a feed-forward circuit in the Drosophila larval nerve cord. Wang YW, et al. Elife, 2022 Jun 20. PMID 35723253, Free PMC Article
  5. Two-color whole-mount in situ hybridization to vertebrate and Drosophila embryos. Hauptmann G, et al. Trends Genet, 1994 Aug. PMID 7940754

See all (268) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The phosphorylation of Hbn, Ems, and Msh may provide further insight into the function of Hipk during development of the Drosophila nervous system.
    Title: Drosophila Homeodomain-Interacting Protein Kinase (Hipk) Phosphorylates the Homeodomain Proteins Homeobrain, Empty Spiracles, and Muscle Segment Homeobox.
  2. Expression and function of empty spiracles gene in olfactory sense organ development.
    Title: Expression and function of the empty spiracles gene in olfactory sense organ development of Drosophila melanogaster.
  3. These results indicate that the anteroposterior patterning gene ems controls the expression of DV genes, and vice versa.
    Title: Ems and Nkx6 are central regulators in dorsoventral patterning of the Drosophila brain.
  4. Data show that Drosophila olfactory local interneurons and projection neurons derive from a common neuroblast lineage specified by the empty spiracles gene.
    Title: Drosophila olfactory local interneurons and projection neurons derive from a common neuroblast lineage specified by the empty spiracles gene.
  5. ems is required for the olfactory circuitry.
    Title: Empty spiracles is required for the development of olfactory projection neuron circuitry in Drosophila.
  6. Data show that ems gene is involved in the specification of the anterior brain during embryonic CNS development in Drosophila.
    Title: Anteroposterior regionalization of the brain: genetic and comparative aspects.
  7. ems is expressed in the mature adult brain and is autonomously required for the correct number of cells in the persistently expressing adult-specific lineage.
    Title: Cell lineage-specific expression and function of the empty spiracles gene in adult brain development of Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterior head segmentation TAS
Traceable Author Statement
more info
 PubMed 
involved_in axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in brain development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in brain segmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic development via the syncytial blastoderm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuroblast development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in open tracheal system development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pattern specification process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spiracle morphogenesis, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ventral cord development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
empty spiracles
Names
CG2988-PA
antenna
empty spiracle
empty-spiracle
empty-spiracles
ems-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13901853..13904620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169560.2 → NP_731868.1  empty spiracles [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731868.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P18488, Q9VFQ1
    UniProtKB/TrEMBL
    Q5BIB4
    Related
    FBpp0082326
    Conserved Domains (1) summary
    pfam00046
    Location:392 → 444
    Homeobox; Homeobox domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18488.2 P18488
Q5BIB4 Q5BIB4

Gene LinkOut

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