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flfl falafel [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41675, updated on 9-Dec-2024

Summary

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Official Symbol
flflprovided by FlyBase
Official Full Name
falafelprovided by FlyBase
Primary source
FLYBASE:FBgn0024555
Locus tag
Dmel_CG9351
See related
AllianceGenome:FB:FBgn0024555
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9351; Dmel\CG9351; Flfl; l(3)L4179; PP4R3; Ppp4R3
Summary
Predicted to enable protein phosphatase activator activity. Involved in several processes, including asymmetric neuroblast division; basal protein localization; and negative regulation of peptidoglycan recognition protein signaling pathway. Located in chromosome, centromeric region; cytoplasm; and nucleus. Part of protein phosphatase 4 complex. Is expressed in several structures, including adult head; anterior endoderm anlage; central brain primordium; ganglia; and mesoderm. Orthologous to several human genes including PPP4R3A (protein phosphatase 4 regulatory subunit 3A) and PPP4R3B (protein phosphatase 4 regulatory subunit 3B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See flfl in Genome Data Viewer
Location:
87F10-87F11; 3-54 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13683921..13693905)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9509643..9519627)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene TWIK-related acid-sensitive K[+] channel 6 Neighboring gene uncharacterized protein Neighboring gene Lkb1 kinase Neighboring gene oocyte maintenance defects Neighboring gene uncharacterized protein Neighboring gene flyers-cup Neighboring gene neither inactivation nor afterpotential B Neighboring gene Adenosine deaminase-related growth factor D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of flfl Triggers JNK-Dependent Cell Death in Drosophila. Huang J, et al. Biomed Res Int, 2015. PMID 26583122, Free PMC Article
  2. Phosphorylation and dephosphorylation events allow for rapid segregation of fate determinants during Drosophila neuroblast asymmetric divisions. Sousa-Nunes R, et al. Commun Integr Biol, 2010 Jan. PMID 20539782, Free PMC Article
  3. Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases. Martin-Granados C, et al. Int J Biochem Cell Biol, 2008. PMID 18487071
  4. Slam protein dictates subcellular localization and translation of its own mRNA. Yan S, et al. PLoS Biol, 2017 Dec. PMID 29206227, Free PMC Article
  5. A fraction of barrier-to-autointegration factor (BAF) associates with centromeres and controls mitosis progression. Torras-Llort M, et al. Commun Biol, 2020 Aug 19. PMID 32814801, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kin17 regulates proper cortical localization of Miranda in Drosophila neuroblasts by regulating Flfl expression.
    Title: Kin17 regulates proper cortical localization of Miranda in Drosophila neuroblasts by regulating Flfl expression.
  2. These data report for the first time an essential physiological function of flfl in maintaining tissue homeostasis and organ development
    Title: Loss of flfl Triggers JNK-Dependent Cell Death in Drosophila.
  3. The binding of Flfl to CENP-C is required to bring PP4 activity to centromeres to maintain CENP-C and attached core kinetochore proteins at chromosomes during mitosis.
    Title: Centromeric binding and activity of Protein Phosphatase 4.
  4. identified the evolutionarily conserved Protein Phosphatase 4 (PP4) regulatory subunit PP4R3/Falafel (Flfl) as a key mediator specific for the localization of Miranda (Mira) and associated cell fate determinants during both interphase and mitosis
    Title: Protein phosphatase 4 mediates localization of the Miranda complex during Drosophila neuroblast asymmetric divisions.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in asymmetric neuroblast division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in basal protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome, centromeric region IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein phosphatase 4 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase 4 complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
falafel
Names
CG9351-PB
CG9351-PD
CG9351-PE
flfl-PB
flfl-PD
flfl-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13683921..13693905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142047.4 → NP_650304.2  falafel, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650304.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VFS5
    Conserved Domains (2) summary
    pfam04802
    Location:169 → 361
    SMK-1; Component of IIS longevity pathway SMK-1
    cl17171
    Location:8 → 66
    PH-like; Pleckstrin homology-like domain

  2. NM_169549.2 → NP_731850.2  falafel, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731850.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MSX6, Q9VFS5
    UniProtKB/TrEMBL
    A0A0C4DHE6
    Conserved Domains (2) summary
    pfam04802
    Location:169 → 361
    SMK-1; Component of IIS longevity pathway SMK-1
    cl17171
    Location:8 → 66
    PH-like; Pleckstrin homology-like domain

  3. NM_169548.3 → NP_731849.2  falafel, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731849.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MSX6, Q9VFS5
    UniProtKB/TrEMBL
    A0A0C4DHE6
    Conserved Domains (2) summary
    pfam04802
    Location:169 → 361
    SMK-1; Component of IIS longevity pathway SMK-1
    cl17171
    Location:8 → 66
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0C4DHE6 A0A0C4DHE6
Q8MSW1 Q8MSW1
Q9VFS5.4 Q9VFS5

Gene LinkOut

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