Su(var)3-7 Suppressor of variegation 3-7 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Su(var)3-7provided by FlyBase
Official Full Name: Suppressor of variegation 3-7provided by FlyBase
Primary source: FLYBASE:FBgn0003598
Locus tag: Dmel_CG8599
See related: AllianceGenome:FB:FBgn0003598
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8599; Dmel\CG8599; DmSu(var)3-7; l(3)87El; Su(var)(3)3; Su(var)(3)7; Su(Var)3-7; SU(VAR)3-7; Su-var(3)7; Suv3-7; Suvar(3)7; Suvar37
Summary: Enables chromatin binding activity. Involved in dosage compensation by hyperactivation of X chromosome and positive regulation of pericentric heterochromatin formation. Located in nucleus and pericentric heterochromatin. Is expressed in several structures, including antennal anlage; antennal primordium; embryonic/larval midgut primordium; ganglia; and head epidermis primordium. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 87E3-87E3; 3-53 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (13264364..13270038)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (9090086..9095760)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results lead us to propose that the interaction between Su(var)3-7 and piwi or aubergine controls important developmental processes independently of transposon silencing.
Title: The Drosophila Su(var)3-7 gene is required for oogenesis and female fertility, genetically interacts with piwi and aubergine, but impacts only weakly transposon silencing.
Data show that in the absence of JIL-1 kinase activity, Su(var)3-7 gets redistributed and upregulated on the chromosome arms.
Title: JIL-1 and Su(var)3-7 interact genetically and counteract each other's effect on position-effect variegation in Drosophila.
Su(var)3-7 expression is sufficient to induce Su(var)3-9-dependent ectopic heterochromatinisation; there may be a functional link between Su(var)3-7 and the histone-methyltransferase Su(var)3-9
Title: Increased expression of Drosophila Su(var)3-7 triggers Su(var)3-9-dependent heterochromatin formation.
isolation of three mutations
Title: Isolation of Su(var)3-7 mutations by homologous recombination in Drosophila melanogaster.
delineation of functional domains which drive binding to heterochromatin and silencing functions
Title: Conserved domains control heterochromatin localization and silencing properties of SU(VAR)3-7.
Although structurally very different, Su(var)3-7 and HP1 participate closely in chromocenter and male X polytene chromosome integrity.
Title: Loss of the modifiers of variegation Su(var)3-7 or HP1 impacts male X polytene chromosome morphology and dosage compensation.
Mutations can suppress w+ variegation if w+ transgene integrates into Chromosome 4.
Title: Mutations in Su(var)205 and Su(var)3-7 suppress P-element-dependent silencing in Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in dosage compensation by hyperactivation of X chromosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of pericentric heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in pericentric heterochromatin	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: suppressor of variegation 3-7

Names: CG8599-PA; CG8599-PB; Su(var)3-7-PA; Su(var)3-7-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

13264364..13270038

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079618.4 → NP_524342.3 suppressor of variegation 3-7, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524342.3

Status: REVIEWED

UniProtKB/Swiss-Prot

P20193, Q9VFX7

UniProtKB/TrEMBL

G2J630

Related

FBpp0082204

Conserved Domains (1) summary

pfam02944
Location:991 → 1021

BESS; BESS motif
NM_001170130.2 → NP_001163601.1 suppressor of variegation 3-7, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163601.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JIJ9, G2J630

Conserved Domains (1) summary

pfam02944
Location:989 → 1019

BESS; BESS motif