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2mit 2mit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41616, updated on 4-Jan-2025

Summary

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Official Symbol
2mitprovided by FlyBase
Official Full Name
2mitprovided by FlyBase
Primary source
FLYBASE:FBgn0260793
Locus tag
Dmel_CG42573
See related
AllianceGenome:FB:FBgn0260793
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10148; CG17319; CG42573; CT28541; CT38314; Dmel\CG42573
Old locus tag
Dmel_CG10148; Dmel_CG17319
Summary
Involved in short-term memory. Is expressed in several structures, including Kenyon cell; adult gnathal ganglion; adult head; ellipsoid body; and presumptive embryonic/larval nervous system. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See 2mit in Genome Data Viewer
Location:
87D13-87D14; 3-53 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13121951..13155687, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8947673..8981409, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene timeout Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46019 Neighboring gene long non-coding RNA:CR45109 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arginine kinase interacts with 2MIT and is involved in Drosophila melanogaster short-term memory. Bozzato A, et al. J Insect Physiol, 2020 Nov-Dec. PMID 33011181
  2. Visualization of binding patterns for five Leucine-rich repeat proteins in the Drosophila embryo. Bali N, et al. MicroPubl Biol, 2019 Dec 18. PMID 32550403, Free PMC Article
  3. Drosophila timeless2 is required for chromosome stability and circadian photoreception. Benna C, et al. Curr Biol, 2010 Feb 23. PMID 20153199
  4. 2mit, an intronic gene of Drosophila melanogaster timeless2, is involved in behavioral plasticity. Baggio F, et al. PLoS One, 2013. PMID 24098788, Free PMC Article
  5. Evidence of abundant stop codon readthrough in Drosophila and other metazoa. Jungreis I, et al. Genome Res, 2011 Dec. PMID 21994247, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arginine kinase interacts with 2MIT and is involved in Drosophila melanogaster short-term memory.
    Title: Arginine kinase interacts with 2MIT and is involved in Drosophila melanogaster short-term memory.
  2. 2mit, an intronic gene of Drosophila melanogaster timeless2, is involved in behavioral plasticity.
    Title: 2mit, an intronic gene of Drosophila melanogaster timeless2, is involved in behavioral plasticity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c13148607-13143088 mobile_element_type = transposon:mdg3{}1351

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in short-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
2mit
Names
2mit-PA
2mit-PB
2mit-PC
2mit-PD
CG42573-PA
CG42573-PB
CG42573-PC
CG42573-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13121951..13155687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142001.4 → NP_650258.2  2mit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650258.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VFY9
    Conserved Domains (4) summary
    cd00116
    Location:124 → 355
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:172 → 194
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:379 → 415
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:193 → 253
    LRR_8; Leucine rich repeat

  2. NM_001275600.2 → NP_001262529.1  2mit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262529.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFU1
    Conserved Domains (4) summary
    cd00116
    Location:124 → 355
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:172 → 194
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:379 → 415
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:193 → 253
    LRR_8; Leucine rich repeat

  3. NM_001300382.1 → NP_001287311.1  2mit, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287311.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VFY9
    Conserved Domains (4) summary
    cd00116
    Location:124 → 355
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:172 → 194
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:379 → 415
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:193 → 253
    LRR_8; Leucine rich repeat

  4. NM_001300381.1 → NP_001287310.1  2mit, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287310.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VFY9
    Conserved Domains (4) summary
    cd00116
    Location:124 → 355
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:172 → 194
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:379 → 415
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:193 → 253
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFU1 A0A0B4KFU1
Q9VFY9 Q9VFY9

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