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Su(fu) - Suppressor of fused

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; molecular sequestering activity; and nuclear localization sequence binding activity. Involved in cytoplasmic sequestering of protein; negative regulation of nucleocytoplasmic transport; and negative regulation of smoothened signaling pathway. Located in cytosol and nucleus. Part of protein-containing complex. Is expressed in organism. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome 2. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling). [provided by Alliance of Genome Resources, Dec 2024]

Genes similar to Su(fu)

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Species Gene Architecture aa