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Not10 CCR4-NOT transcription complex subunit 10 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41552, updated on 9-Dec-2024

Summary

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Official Symbol
Not10provided by FlyBase
Official Full Name
CCR4-NOT transcription complex subunit 10provided by FlyBase
Primary source
FLYBASE:FBgn0260444
Locus tag
Dmel_CG18616
See related
AllianceGenome:FB:FBgn0260444
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18616; Dmel\CG18616; dNot10; NOT10
Old locus tag
CG18616
Summary
Involved in mRNA catabolic process and negative regulation of translation. Part of CCR4-NOT complex. Is expressed in spermatozoon. Orthologous to human CNOT10 (CCR4-NOT transcription complex subunit 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Not10 in Genome Data Viewer
Location:
87C3-87C3; 3-52 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12630647..12633188)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8456369..8458747)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Vacuolar H[+]-ATPase 55kD subunit Neighboring gene Sorting nexin 3 Neighboring gene antisense RNA:CR46018 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure and assembly of the NOT10:11 module of the CCR4-NOT complex. Levdansky Y, et al. Commun Biol, 2023 Jul 17. PMID 37460791, Free PMC Article
  2. In Vitro Reconstitution of the Drosophila melanogaster CCR4-NOT Complex to Assay Deadenylation. Pekovic F, et al. Methods Mol Biol, 2024. PMID 37824062
  3. NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. Bawankar P, et al. RNA Biol, 2013 Feb. PMID 23303381, Free PMC Article
  4. A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin. Sgromo A, et al. Nat Commun, 2017 Feb 6. PMID 28165457, Free PMC Article
  5. RNA binding proteins Smaug and Cup induce CCR4-NOT-dependent deadenylation of the nanos mRNA in a reconstituted system. Pekovic F, et al. Nucleic Acids Res, 2023 May 8. PMID 36951092, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NOT10 and NOT11 form a complex that docks onto the NOT1 scaffold via interactions with NOT11 and the N-terminal NOT1 domain.
    Title: NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CCR4-NOT complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of CCR4-NOT complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CCR4-NOT transcription complex subunit 10
Names
CG18616-PA
CG18616-PB
Not10-PA
Not10-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12630647..12633188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316562.1 → NP_001303491.1  CCR4-NOT transcription complex subunit 10, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SZP3, Q9V3G6
    UniProtKB/TrEMBL
    A0A126GUU0, T1UM80
    Conserved Domains (1) summary
    sd00006
    Location:294 → 318
    TPR; TPR repeat [structural motif]

  2. NM_141958.4 → NP_650215.1  CCR4-NOT transcription complex subunit 10, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650215.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SZP3, Q9V3G6
    UniProtKB/TrEMBL
    A0A126GUU0, T1UM80
    Related
    FBpp0082112
    Conserved Domains (1) summary
    sd00006
    Location:294 → 318
    TPR; TPR repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A126GUU0 A0A126GUU0
Q9V3G6.1 Q9V3G6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Chemical Information
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