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CG5608 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41543, updated on 9-Dec-2024

Summary

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Official Symbol
CG5608provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0038058
Locus tag
Dmel_CG5608
See related
AllianceGenome:FB:FBgn0038058
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG5608; Vac14
Summary
Predicted to be involved in phosphatidylinositol biosynthetic process. Predicted to be part of PAS complex. Predicted to be active in endosome membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in striatonigral degeneration. Orthologous to human VAC14 (VAC14 component of PIKFYVE complex). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG5608 in Genome Data Viewer
Location:
87B11-87B12; 3-52 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12462562..12465298, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8288284..8291020, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene toys are us Neighboring gene uncharacterized protein Neighboring gene RNA polymerase III subunit C Neighboring gene Heat shock protein 70 Ba Neighboring gene alphagamma-element:CR32865

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FIG4 regulates lysosome membrane homeostasis independent of phosphatase function. Bharadwaj R, et al. Hum Mol Genet, 2016 Feb 15. PMID 26662798, Free PMC Article
  2. Hsp70 duplication in the Drosophila melanogaster species group: how and when did two become five? Bettencourt BR, et al. Mol Biol Evol, 2001 Jul. PMID 11420366
  3. Chromatin-associated RNA interference components contribute to transcriptional regulation in Drosophila. Cernilogar FM, et al. Nature, 2011 Nov 6. PMID 22056986, Free PMC Article
  4. Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Mummery-Widmer JL, et al. Nature, 2009 Apr 23. PMID 19363474, Free PMC Article
  5. Systematic analysis of the Frazzled receptor interactome establishes previously unreported regulators of axon guidance. Zang Y, et al. Development, 2023 Aug 1. PMID 37526651, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in phosphatidylinositol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of PAS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PAS complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5608-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12462562..12465298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141951.1 → NP_650208.1  uncharacterized protein Dmel_CG5608 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650208.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T989, Q9VG59
    Related
    FBpp0082148, FBtr0082680
    Conserved Domains (3) summary
    pfam11916
    Location:452 → 629
    Vac14_Fig4_bd; Vacuolar protein 14 C-terminal Fig4p binding
    pfam12755
    Location:65 → 161
    Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region
    sd00044
    Location:45 → 79
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T989 Q8T989
Q9VG59 Q9VG59

Gene LinkOut

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