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Aos1 Activator of SUMO 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41532, updated on 4-Jan-2025

Summary

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Official Symbol
Aos1provided by FlyBase
Official Full Name
Activator of SUMO 1provided by FlyBase
Primary source
FLYBASE:FBgn0029512
Locus tag
Dmel_CG12276
See related
AllianceGenome:FB:FBgn0029512
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Aos; AOS1; CG12276; Dmaos1; DmAos1; Dmel\CG12276; DmSae1; DmSAE1; Sae1; SAE1
Summary
Enables ubiquitin activating enzyme binding activity and ubiquitin conjugating enzyme binding activity. Contributes to SUMO activating enzyme activity. Involved in several processes, including positive regulation of Toll signaling pathway; positive regulation of antimicrobial peptide production; and protein sumoylation. Located in nucleus. Is expressed in several structures, including Malpighian tubule primordium; antennal anlage; ganglia; germline cell; and head epidermis primordium. Used to study hematologic cancer. Orthologous to human SAE1 (SUMO1 activating enzyme subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Aos1 in Genome Data Viewer
Location:
87B10-87B10; 3-52 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12432533..12433822, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8258255..8259544, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene N-acetylneuraminic acid synthase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Proteasome alpha2 subunit Neighboring gene Spliceosome-ribosome linker protein Neighboring gene Desaturase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sumoylation is tumor-suppressive and confers proliferative quiescence to hematopoietic progenitors in Drosophila melanogaster larvae. Kalamarz ME, et al. Biol Open, 2012 Mar 15. PMID 23213407, Free PMC Article
  2. Expression of genes involved in sumoylation in the Drosophila germline. Hashiyama K, et al. Gene Expr Patterns, 2009 Jan. PMID 18755298
  3. Identification and characterization of a SUMO-1 conjugation system that modifies neuronal calcium/calmodulin-dependent protein kinase II in Drosophila melanogaster. Long X, et al. J Biol Chem, 2000 Dec 29. PMID 10995744
  4. Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery. Andreev VI, et al. Nat Struct Mol Biol, 2022 Feb. PMID 35173350
  5. Drosophila CP190- and dCTCF-mediated enhancer blocking is augmented by SUMOylation. Jox T, et al. Epigenetics Chromatin, 2017. PMID 28680483, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to SUMO activating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin activating enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-like modifier activating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of Toll signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of antimicrobial peptide production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein sumoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SUMO activating enzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
activator of SUMO 1
Names
Aos1-PA
CG12276-PA
Smt3 activating enzyme 1
ubiquitin activating enzyme
ubiquitin activating enzyme 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12432533..12433822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141941.3 → NP_650198.1  activator of SUMO 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650198.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0ANV4, A0ANV7, A0ANV9, Q7KJV5, Q7KSM5, Q9U4A0, Q9VG70
    Related
    FBpp0082065
    Conserved Domains (2) summary
    cd01492
    Location:19 → 172
    Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    pfam00899
    Location:22 → 167
    ThiF; ThiF family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KJV5 Q7KJV5
Q7KSM5 Q7KSM5
Q9VG70 Q9VG70

Gene LinkOut

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