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ndufa1 NADH:ubiquinone oxidoreductase subunit A1 [ Danio rerio (zebrafish) ]

Gene ID: 415243, updated on 4-Jan-2025

Summary

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Official Symbol
ndufa1provided by ZNC
Official Full Name
NADH:ubiquinone oxidoreductase subunit A1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040625-168
See related
Ensembl:ENSDARG00000036329 AllianceGenome:ZFIN:ZDB-GENE-040625-168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:86674
Summary
Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 12. Orthologous to human NDUFA1 (NADH:ubiquinone oxidoreductase subunit A1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See ndufa1 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (33413960..33415439)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (33073646..33075125)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 118 Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 210 Neighboring gene NFKB activating protein Neighboring gene zinc finger and BTB domain containing 33 Neighboring gene transmembrane protein 255A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis. Burkhalter MD, et al. J Clin Invest, 2019 May 16. PMID 31094706, Free PMC Article
  2. Aclonifen causes developmental abnormalities in zebrafish embryos through mitochondrial dysfunction and oxidative stress. Lee JY, et al. Sci Total Environ, 2021 Jun 1. PMID 33548715
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
Names
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1
NP_001002153.2
NP_001161327.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002153.3 → NP_001002153.2  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

    See identical proteins and their annotated locations for NP_001002153.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC071358, BX571981
    UniProtKB/TrEMBL
    A0A8M1NSZ8, F1QQ42, Q6IQP6
    Related
    ENSDARP00000105154.2, ENSDART00000124437.3
    Conserved Domains (1) summary
    pfam15879
    Location:5 → 56
    MWFE; NADH-ubiquinone oxidoreductase MWFE subunit

  2. NM_001167855.2 → NP_001161327.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

    See identical proteins and their annotated locations for NP_001161327.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC071358, BX571981, EH451895
    UniProtKB/TrEMBL
    A0A8M1NSZ8, F1QQ42, Q6IQP6
    Related
    ENSDARP00000052779.3, ENSDART00000052780.5
    Conserved Domains (1) summary
    pfam15879
    Location:5 → 56
    MWFE; NADH-ubiquinone oxidoreductase MWFE subunit

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    33413960..33415439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394917.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    377829..379308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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