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Tim17a1 Tim17a1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41500, updated on 4-Jan-2025

Summary

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Official Symbol
Tim17a1provided by FlyBase
Official Full Name
Tim17a1provided by FlyBase
Primary source
FLYBASE:FBgn0038018
Locus tag
Dmel_CG10090
See related
AllianceGenome:FB:FBgn0038018
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10090; Dmel\CG10090; Tim17 a1
Summary
Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Is expressed in adult head and spermatozoon. Orthologous to human TIMM17B (translocase of inner mitochondrial membrane 17B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Tim17a1 in Genome Data Viewer
Location:
87B8-87B8; 3-52 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12363667..12364680, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8189389..8190402, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene MBD-R2 Neighboring gene uncharacterized protein Neighboring gene small non-coding RNA 419 Neighboring gene Glutathione S transferase D10 Neighboring gene Glutathione S transferase D9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolution of the Tim17 protein family. Žárský V, et al. Biol Direct, 2016 Oct 19. PMID 27760563, Free PMC Article
  2. Molecular population genetics of accessory gland protein genes and testis-expressed genes in Drosophila mojavensis and D. arizonae. Wagstaff BJ, et al. Genetics, 2005 Nov. PMID 16085702, Free PMC Article
  3. Heat shock protein 83 (Hsp83) facilitates methoprene-tolerant (Met) nuclear import to modulate juvenile hormone signaling. He Q, et al. J Biol Chem, 2014 Oct 3. PMID 25122763, Free PMC Article
  4. Mitochondrial-Y chromosome epistasis in Drosophila melanogaster. Ågren JA, et al. Proc Biol Sci, 2020 Oct 28. PMID 33081607, Free PMC Article
  5. Identification of genetic modifiers of TDP-43 neurotoxicity in Drosophila. Zhan L, et al. PLoS One, 2013. PMID 23468938, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Tim17a1
Names
CG10090-PA
CG10090-PB
Tim17a1-PA
Tim17a1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12363667..12364680 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141923.2 → NP_650180.1  Tim17a1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650180.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5RJ92, Q8MZE4, Q9VGA2
    UniProtKB/TrEMBL
    A0A0B4LH92
    Related
    FBpp0082080, FBtr0082610
    Conserved Domains (1) summary
    cl02381
    Location:2 → 138
    Tim17; Tim17/Tim22/Tim23/Pmp24 family

  2. NM_001300372.1 → NP_001287301.1  Tim17a1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287301.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5RJ92, Q8MZE4, Q9VGA2
    UniProtKB/TrEMBL
    A0A0B4LH92
    Conserved Domains (1) summary
    cl02381
    Location:2 → 138
    Tim17; Tim17/Tim22/Tim23/Pmp24 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LH92 A0A0B4LH92
Q9VGA2.1 Q9VGA2

Gene LinkOut

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