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MBD-R2 MBD-R2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41498, updated on 9-Dec-2024

Summary

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Official Symbol
MBD-R2provided by FlyBase
Official Full Name
MBD-R2provided by FlyBase
Primary source
FLYBASE:FBgn0038016
Locus tag
Dmel_CG10042
See related
AllianceGenome:FB:FBgn0038016
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10042; CG17393; Dm Tam3; dMBD-R2; Dmel\CG10042; MBD; mbd-R2; MBD-R2/NSL; Mbdr2; MBDR2; Mbrd2; TAM3
Summary
Enables promoter-specific chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in euchromatin; nucleus; and polytene chromosome interband. Part of NSL complex. Is expressed in organism and spermatozoon. Orthologous to human PHF20 (PHD finger protein 20) and PHF20L1 (PHD finger protein 20 like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See MBD-R2 in Genome Data Viewer
Location:
87B7-87B8; 3-52 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12352143..12356265, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8177865..8181987, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene small non-coding RNA 419 Neighboring gene Tim17a1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Methyl-CpG binding domain proteins inhibit interspecies courtship and promote aggression in Drosophila. Gupta T, et al. Sci Rep, 2017 Jul 14. PMID 28710457, Free PMC Article
  2. Functional conservation of MBD proteins: MeCP2 and Drosophila MBD proteins alter sleep. Gupta T, et al. Genes Brain Behav, 2016 Nov. PMID 27489246, Free PMC Article
  3. Now you see it: genome methylation makes a comeback in Drosophila. Boffelli D, et al. Bioessays, 2014 Dec. PMID 25220261
  4. The NSL complex regulates housekeeping genes in Drosophila. Lam KC, et al. PLoS Genet, 2012. PMID 22723752, Free PMC Article
  5. An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis. Meunier S, et al. Nat Commun, 2015 Aug 5. PMID 26243146, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NSL complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome interband IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MBD-R2
Names
CG10042-PB
MBD-R2-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12352143..12356265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169461.3 → NP_731688.2  MBD-R2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731688.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VGA4
    UniProtKB/TrEMBL
    Q7KSN0
    Related
    FBpp0082081
    Conserved Domains (4) summary
    cd04508
    Location:292 → 329
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd01396
    Location:449 → 522
    MeCP2_MBD; MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding ...
    pfam05485
    Location:4 → 86
    THAP; THAP domain
    cl22851
    Location:919 → 963
    PHD_SF; PHD finger superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KSN0 Q7KSN0
Q9VGA4 Q9VGA4

Gene LinkOut

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