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KLHL18 Kelch like family member 18 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41458, updated on 4-Jan-2025

Summary

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Official Symbol
KLHL18provided by FlyBase
Official Full Name
Kelch like family member 18provided by FlyBase
Primary source
FLYBASE:FBgn0037978
Locus tag
Dmel_CG3571
See related
AllianceGenome:FB:FBgn0037978
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.179; CG3571; dKLHL18; Dmel\CG3571
Summary
Enables ubiquitin-like ligase-substrate adaptor activity. Involved in imaginal disc fusion, thorax closure and proteasome-mediated ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin ligase complex. Is expressed in organism. Orthologous to human KLHL18 (kelch like family member 18). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See KLHL18 in Genome Data Viewer
Location:
87A4-87A5; 3-51 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12007476..12010434, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7833198..7836156, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene midline fasciclin Neighboring gene Tachykinin Neighboring gene Ectoderm-expressed 3 Neighboring gene GRIP and coiled-coil domain containing 185 kDa Neighboring gene DDB1 and CUL4 associated factor 12 Neighboring gene Spt3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. BTB protein, dKLHL18/CG3571, serves as an adaptor subunit for a dCul3 ubiquitin ligase complex. Fujiyama-Nakamura S, et al. Genes Cells, 2009 Aug. PMID 19624754
  2. Stability of HIB-Cul3 E3 ligase adaptor HIB Is Regulated by Self-degradation and Availability of Its Substrates. Zhou Z, et al. Sci Rep, 2015 Aug 12. PMID 26263855, Free PMC Article
  3. Genetic link between heme oxygenase and the signaling pathway of DNA damage in Drosophila melanogaster. Ida H, et al. Tohoku J Exp Med, 2013 Oct. PMID 24126234
  4. Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death. Cao C, et al. J Cell Biol, 2007 Mar 12. PMID 17339378, Free PMC Article
  5. Identification and investigation of Drosophila postsynaptic density homologs. Liebl FL, et al. Bioinform Biol Insights, 2008 Nov 3. PMID 19812789, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in imaginal disc fusion, thorax closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Cul3-RING ubiquitin ligase complex IGI
Inferred from Genetic Interaction
more info
 PubMed 
part_of Cul3-RING ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kelch like family member 18
Names
CG3571-PA
CG3571-PB
CG3571-PC
KLHL18-PA
KLHL18-PB
KLHL18-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12007476..12010434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275565.1 → NP_001262494.1  kelch like family member 18, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262494.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VGE5
    Conserved Domains (6) summary
    smart00612
    Location:340 → 386
    Kelch; Kelch domain
    PHA03098
    Location:36 → 510
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:423 → 466
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:29 → 135
    BTB; BTB/POZ domain
    pfam01344
    Location:469 → 514
    Kelch_1; Kelch motif
    pfam07707
    Location:143 → 245
    BACK; BTB And C-terminal Kelch

  2. NM_141886.3 → NP_650143.1  kelch like family member 18, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650143.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VGE5
    Related
    FBpp0082029
    Conserved Domains (6) summary
    smart00612
    Location:340 → 386
    Kelch; Kelch domain
    PHA03098
    Location:36 → 510
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:423 → 466
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:29 → 135
    BTB; BTB/POZ domain
    pfam01344
    Location:469 → 514
    Kelch_1; Kelch motif
    pfam07707
    Location:143 → 245
    BACK; BTB And C-terminal Kelch

  3. NM_169446.2 → NP_731664.1  kelch like family member 18, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731664.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VGE6
    Related
    FBpp0082030
    Conserved Domains (6) summary
    smart00612
    Location:303 → 349
    Kelch; Kelch domain
    PHA03098
    Location:15 → 473
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:386 → 429
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:6 → 98
    BTB; BTB/POZ domain
    pfam01344
    Location:432 → 477
    Kelch_1; Kelch motif
    pfam07707
    Location:106 → 208
    BACK; BTB And C-terminal Kelch
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VGE5 Q9VGE5
Q9VGE6 Q9VGE6

Gene LinkOut

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