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mfas midline fasciclin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41455, updated on 4-Jan-2025

Summary

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Official Symbol
mfasprovided by FlyBase
Official Full Name
midline fasciclinprovided by FlyBase
Primary source
FLYBASE:FBgn0260745
Locus tag
Dmel_CG3359
See related
AllianceGenome:FB:FBgn0260745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
87A7-9/7; anon-87Af; anon-EST:Liang-97; anon-WO0140519.174; BEST:GH06752; CG3359; clone 97; Dmel\CG3359; FBgn0260745; gh06752; Mfas
Summary
Predicted to enable cell adhesion molecule binding activity. Involved in axonogenesis and negative regulation of hemocyte proliferation. Located in extracellular space. Is expressed in several structures, including anlage in statu nascendi; epithelium; follicle cell; gut section; and midline glial cell. Human ortholog(s) of this gene implicated in congestive heart failure and corneal dystrophy (multiple). Orthologous to several human genes including TGFBI (transforming growth factor beta induced). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See mfas in Genome Data Viewer
Location:
87A4-87A4; 3-51 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11984862..11993315, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7810584..7819037, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Tachykinin Neighboring gene Ectoderm-expressed 3 Neighboring gene Kelch like family member 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development. Bellosta P, et al. Proc Natl Acad Sci U S A, 2005 Aug 16. PMID 16087886, Free PMC Article
  2. Midline Fasciclin: a Drosophila Fasciclin-I-related membrane protein localized to the CNS midline cells and trachea. Hu S, et al. J Neurobiol, 1998 Apr. PMID 9552168
  3. Enhancer diversity and the control of a simple pattern of Drosophila CNS midline cell expression. Pearson JC, et al. Dev Biol, 2014 Aug 15. PMID 24854999, Free PMC Article
  4. Genomic imprinting absent in Drosophila melanogaster adult females. Coolon JD, et al. Cell Rep, 2012 Jul 26. PMID 22840398, Free PMC Article
  5. The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy. Graca FA, et al. Nat Commun, 2022 May 2. PMID 35501350, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cell adhesion molecule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of hemocyte proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sexual reproduction HEP PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
midline fasciclin
Names
CG3359-PB
CG3359-PC
CG3359-PD
CG3359-PE
CG3359-PF
CG3359-PG
CG3359-PH
CG3359-PI
CG3359-PJ
CG3359-PK
CG3359-PL
CG3359-PM
CG3359-PN
CG3359-PO
CG3359-PP
CG3359-PQ
anon-87Af
mfas-PB
mfas-PC
mfas-PD
mfas-PE
mfas-PF
mfas-PG
mfas-PH
mfas-PI
mfas-PJ
mfas-PK
mfas-PL
mfas-PM
mfas-PN
mfas-PO
mfas-PP
mfas-PQ
midline fascilin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11984862..11993315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176467.1 → NP_788644.1  midline fasciclin, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788644.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBY2, Q86B97
    Related
    FBpp0081975, FBtr0082501
    Conserved Domains (2) summary
    smart00554
    Location:249 → 360
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:372 → 502
    Fasciclin; Fasciclin domain

  2. NM_169444.1 → NP_731661.1  midline fasciclin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731661.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBY2, Q9VGE9
    Related
    FBpp0081963, FBtr0082489
    Conserved Domains (2) summary
    smart00554
    Location:250 → 361
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:373 → 503
    Fasciclin; Fasciclin domain

  3. NM_176471.1 → NP_788648.1  midline fasciclin, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788648.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61457, Q9VGF0
    Related
    FBpp0081971, FBtr0082497
    Conserved Domains (2) summary
    smart00554
    Location:315 → 426
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:438 → 568
    Fasciclin; Fasciclin domain

  4. NM_176474.1 → NP_788651.1  midline fasciclin, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788651.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBY2, Q86B96
    Related
    FBpp0081976, FBtr0082502
    Conserved Domains (2) summary
    smart00554
    Location:273 → 384
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:396 → 526
    Fasciclin; Fasciclin domain

  5. NM_176476.1 → NP_788653.1  midline fasciclin, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788653.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBY2, E8NH85, Q86B95
    Related
    FBpp0081969, FBtr0082495
    Conserved Domains (2) summary
    smart00554
    Location:274 → 385
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:397 → 527
    Fasciclin; Fasciclin domain

  6. NM_176478.1 → NP_788655.1  midline fasciclin, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788655.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E8NH93, Q86B94
    Related
    FBpp0081972, FBtr0082498
    Conserved Domains (2) summary
    smart00554
    Location:339 → 450
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:462 → 592
    Fasciclin; Fasciclin domain

  7. NM_176466.1 → NP_788643.1  midline fasciclin, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788643.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBY2, Q86B97
    Related
    FBpp0081970, FBtr0082496
    Conserved Domains (2) summary
    smart00554
    Location:249 → 360
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:372 → 502
    Fasciclin; Fasciclin domain

  8. NM_176470.1 → NP_788647.1  midline fasciclin, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788647.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBY2, Q9VGE9
    Related
    FBpp0081965, FBtr0082491
    Conserved Domains (2) summary
    smart00554
    Location:250 → 361
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:373 → 503
    Fasciclin; Fasciclin domain

  9. NM_176472.1 → NP_788649.1  midline fasciclin, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788649.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61457, Q9VGF0
    Related
    FBpp0081973, FBtr0082499
    Conserved Domains (2) summary
    smart00554
    Location:315 → 426
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:438 → 568
    Fasciclin; Fasciclin domain

  10. NM_176473.1 → NP_788650.1  midline fasciclin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788650.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBY2, Q86B96
    Related
    FBpp0081967, FBtr0082493
    Conserved Domains (2) summary
    smart00554
    Location:273 → 384
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:396 → 526
    Fasciclin; Fasciclin domain

  11. NM_176477.1 → NP_788654.1  midline fasciclin, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788654.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBY2, E8NH85, Q86B95
    Related
    FBpp0081974, FBtr0082500
    Conserved Domains (2) summary
    smart00554
    Location:274 → 385
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:397 → 527
    Fasciclin; Fasciclin domain

  12. NM_176469.2 → NP_788646.1  midline fasciclin, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788646.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBY2, Q9VGE9
    Related
    FBpp0081977
    Conserved Domains (2) summary
    smart00554
    Location:250 → 361
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:373 → 503
    Fasciclin; Fasciclin domain

  13. NM_079600.3 → NP_524324.2  midline fasciclin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524324.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61457, Q9VGF0
    Related
    FBpp0081964
    Conserved Domains (2) summary
    smart00554
    Location:315 → 426
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:438 → 568
    Fasciclin; Fasciclin domain

  14. NM_176468.1 → NP_788645.1  midline fasciclin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788645.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBY2, Q9VGE9
    Related
    FBpp0081966, FBtr0082492
    Conserved Domains (2) summary
    smart00554
    Location:250 → 361
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:373 → 503
    Fasciclin; Fasciclin domain

  15. NM_176475.1 → NP_788652.1  midline fasciclin, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788652.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBY2, E8NH85, Q86B95
    Related
    FBpp0081968, FBtr0082494
    Conserved Domains (2) summary
    smart00554
    Location:274 → 385
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:397 → 527
    Fasciclin; Fasciclin domain

  16. NM_001260137.1 → NP_001247066.1  midline fasciclin, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247066.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3DMM4, E6PBY2
    Conserved Domains (2) summary
    smart00554
    Location:230 → 341
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:353 → 483
    Fasciclin; Fasciclin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3DMM4 D3DMM4
O61457 O61457
Q86B94 Q86B94
Q86B95 Q86B95
Q86B96 Q86B96
Q86B97 Q86B97
Q9VGE9 Q9VGE9
Q9VGF0 Q9VGF0

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