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CG31368 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41437, updated on 4-Jan-2025

Summary

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Official Symbol
CG31368provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0051368
Locus tag
Dmel_CG31368
See related
AllianceGenome:FB:FBgn0051368
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14729; CG14730; Dmel\CG31368; Salsa
Summary
Predicted to enable 3'-5' RNA helicase activity; mRNA binding activity; and single-stranded RNA binding activity. Involved in mRNA splicing, via spliceosome. Part of Prp19 complex. Is expressed in several structures, including central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; ganglia; and larval nervous system. Orthologous to human AQR (aquarius intron-binding spliceosomal factor). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG31368 in Genome Data Viewer
Location:
87A1-87A1; 3-51 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11882790..11892382)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7708512..7718104)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene shadow Neighboring gene methuselah-like 5 Neighboring gene Dynein axonemal light intermediate chain 1 Neighboring gene Cadherin 87A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gia/Mthl5 is an aorta specific GPCR required for Drosophila heart tube morphology and normal pericardial cell positioning. Patel MV, et al. Dev Biol, 2016 Jun 1. PMID 26994946, Free PMC Article
  2. Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state. Le Thomas A, et al. Genes Dev, 2013 Feb 15. PMID 23392610, Free PMC Article
  3. Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer. Liu J, et al. Science, 2009 Feb 27. PMID 19164706, Free PMC Article
  4. NineTeen Complex-subunit Salsa is required for efficient splicing of a subset of introns and dorsal-ventral patterning. Rathore OS, et al. RNA, 2020 Dec. PMID 32963109, Free PMC Article
  5. Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development. Guilgur LG, et al. Elife, 2014 Apr 22. PMID 24755291, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 3'-5' RNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Prp19 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of catalytic step 2 spliceosome HDA PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of precatalytic spliceosome HDA PubMed 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG31368-PC
CG31368-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11882790..11892382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206476.3 → NP_996198.2  uncharacterized protein Dmel_CG31368, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996198.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KSN8
    Conserved Domains (5) summary
    COG1112
    Location:1012 → 1348
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam13086
    Location:818 → 1123
    AAA_11; AAA domain
    pfam13245
    Location:821 → 893
    AAA_19; Part of AAA domain
    pfam16399
    Location:33 → 815
    Aquarius_N; Intron-binding protein aquarius N-terminus
    cl22977
    Location:1131 → 1321
    UvrD_C_2; UvrD-like helicase C-terminal domain

  2. NM_169439.4 → NP_731647.3  uncharacterized protein Dmel_CG31368, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731647.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YU45, Q9VGG9
    Conserved Domains (5) summary
    COG1112
    Location:1012 → 1337
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam13086
    Location:818 → 1123
    AAA_11; AAA domain
    pfam13245
    Location:821 → 893
    AAA_19; Part of AAA domain
    pfam16399
    Location:33 → 815
    Aquarius_N; Intron-binding protein aquarius N-terminus
    cl22977
    Location:1131 → 1321
    UvrD_C_2; UvrD-like helicase C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KSN8 Q7KSN8
Q8MQK8 Q8MQK8
Q8MSA2 Q8MSA2
Q9VGG9 Q9VGG9

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