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ClC-a Chloride channel-a [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41428, updated on 17-Dec-2024

Summary

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Official Symbol
ClC-aprovided by FlyBase
Official Full Name
Chloride channel-aprovided by FlyBase
Primary source
FLYBASE:FBgn0051116
Locus tag
Dmel_CG31116
See related
AllianceGenome:FB:FBgn0051116
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14726; CG31116; CG6942; CLC-2; Clc-a; DmClC-2; DmClC-a; DmClCa; Dmel\CG31116; FBgn0037951
Summary
Enables chloride channel activity. Involved in chloride transport and water transport. Located in apical plasma membrane and basal plasma membrane. Is expressed in several structures, including Malpighian tubule Type II cell; adult head; embryonic/larval midgut; ganglia; and glial cell. Used to study myopathy. Human ortholog(s) of this gene implicated in several diseases, including idiopathic generalized epilepsy 11; myotonia congenita (multiple); primary hyperaldosteronism; renal tubular transport disease (multiple); and sensorineural hearing loss. Orthologous to several human genes including CLCN2 (chloride voltage-gated channel 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See ClC-a in Genome Data Viewer
Location:
86F8-86F8; 3-51 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11797244..11813207, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7622966..7638929, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pruning defect 1 Neighboring gene Histamine-gated chloride channel subunit 1 Neighboring gene SET domain binding factor Neighboring gene glorund Neighboring gene Cytochrome c oxidase subunit 5A Neighboring gene Kynurenine aminotransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Statins Induce Locomotion and Muscular Phenotypes in Drosophila melanogaster That Are Reminiscent of Human Myopathy: Evidence for the Role of the Chloride Channel Inhibition in the Muscular Phenotypes. Al-Sabri MH, et al. Cells, 2022 Nov 8. PMID 36428957, Free PMC Article
  2. Properties and possible function of a hyperpolarisation-activated chloride current in Drosophila. Rose U, et al. J Exp Biol, 2007 Jul. PMID 17601953
  3. Integrative physiology and functional genomics of epithelial function in a genetic model organism. Dow JT, et al. Physiol Rev, 2003 Jul. PMID 12843407
  4. Drosophila ClC-a is required in glia of the stem cell niche for proper neurogenesis and wiring of neural circuits. Plazaola-Sasieta H, et al. Glia, 2019 Dec. PMID 31479171, Free PMC Article
  5. Glial Chloride Channels in the Function of the Nervous System Across Species. Fernandez-Abascal J, et al. Adv Exp Med Biol, 2021. PMID 35138616, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ClC-a was expressed in the niche in cortex glia and loss-of-function mutations resulted in smaller brains and neural wiring defects.
    Title: Drosophila ClC-a is required in glia of the stem cell niche for proper neurogenesis and wiring of neural circuits.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c11807783-11807583 mobile_element_type = transposon:INE-1{}2915

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chloride channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables voltage-gated chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chloride transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in renal water homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in renal water transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transepithelial chloride transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transepithelial water transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
chloride channel-a
Names
CG31116-PA
CG31116-PC
CG31116-PD
CG31116-PF
CG31116-PG
CG31116-PH
CG31116-PI
ClC-a-PA
ClC-a-PC
ClC-a-PD
ClC-a-PF
ClC-a-PG
ClC-a-PH
ClC-a-PI

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11797244..11813207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104281.2 → NP_001097751.2  chloride channel-a, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097751.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VGH7
    Conserved Domains (3) summary
    cd03683
    Location:123 → 598
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:844 → 921
    CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
    pfam00654
    Location:179 → 567
    Voltage_CLC; Voltage gated chloride channel

  2. NM_001170121.1 → NP_001163592.1  chloride channel-a, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163592.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VGH7
    Conserved Domains (3) summary
    cd03683
    Location:123 → 598
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:952 → 1048
    CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
    pfam00654
    Location:179 → 567
    Voltage_CLC; Voltage gated chloride channel

  3. NM_001275558.1 → NP_001262487.1  chloride channel-a, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262487.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGV4

  4. NM_001104282.3 → NP_001097752.1  chloride channel-a, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097752.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H1UUP0
    Conserved Domains (3) summary
    cd03683
    Location:171 → 646
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:905 → 969
    CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
    cl15354
    Location:659 → 718
    CBS_pair_SF; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily

  5. NM_176462.2 → NP_788639.1  chloride channel-a, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788639.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4VCL3, A8JQX8, A8JQX9, E1JIJ0, Q7YU63, Q8INJ7, Q8MRL4, Q9VGH7, Q9VGH8
    Related
    FBpp0082002
    Conserved Domains (3) summary
    cd03683
    Location:171 → 646
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:1000 → 1096
    CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
    pfam00654
    Location:227 → 615
    Voltage_CLC; Voltage gated chloride channel

  6. NM_169431.3 → NP_731634.2  chloride channel-a, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731634.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VGH7
    Related
    FBpp0082001
    Conserved Domains (3) summary
    cd03683
    Location:154 → 629
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:875 → 952
    CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
    pfam00654
    Location:210 → 598
    Voltage_CLC; Voltage gated chloride channel

  7. NM_169432.3 → NP_731635.2  chloride channel-a, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731635.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VGH7
    Related
    FBpp0082000
    Conserved Domains (3) summary
    cd03683
    Location:154 → 629
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:983 → 1079
    CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
    pfam00654
    Location:210 → 598
    Voltage_CLC; Voltage gated chloride channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGV4 A0A0B4KGV4
Q9VGH7.3 Q9VGH7

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