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HisCl1 - Histamine-gated chloride channel subunit 1

Enables histamine-gated chloride channel activity. Involved in chloride transport and thermotaxis. Part of histamine-gated chloride channel complex. Is expressed in several structures, including adult pacemaker neurons; anterior-posterior subdivision of organism; photoreceptor; photoreceptor neurons; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in hyperekplexia 1 and syndromic X-linked intellectual disability Pilorge type. Orthologous to human GLRA1 (glycine receptor alpha 1) and GLRA2 (glycine receptor alpha 2). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa