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Ho Heme oxygenase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41407, updated on 9-Dec-2024

Summary

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Official Symbol
Hoprovided by FlyBase
Official Full Name
Heme oxygenaseprovided by FlyBase
Primary source
FLYBASE:FBgn0037933
Locus tag
Dmel_CG14716
See related
AllianceGenome:FB:FBgn0037933
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14716; CT34507; dHO; Dmel\CG14716; DmHO; ho; HO; Ho-1; HO-1; HOX
Summary
Enables heme oxygenase (decyclizing) activity. Involved in heme metabolic process. Located in endomembrane system. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); factor VIII deficiency; lung disease (multiple); and sickle cell anemia. Orthologous to several human genes including HMOX1 (heme oxygenase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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Location:
86E15-86E15; 3-51 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11679743..11680976)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7505465..7506698)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TBP-associated factor 12 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Daily Regulation of Phototransduction, Circadian Clock, DNA Repair, and Immune Gene Expression by Heme Oxygenase in the Retina of Drosophila. Damulewicz M, et al. Genes (Basel), 2018 Dec 21. PMID 30583479, Free PMC Article
  2. Haeme oxygenase protects against UV light DNA damages in the retina in clock-dependent manner. Damulewicz M, et al. Sci Rep, 2017 Jul 12. PMID 28701782, Free PMC Article
  3. Lignin-carbohydrate complexes suppress SCA3 neurodegeneration via upregulating proteasomal activities. Chen ZS, et al. Int J Biol Macromol, 2022 Oct 1. PMID 35872311
  4. Interactions Between the Circadian Clock and Heme Oxygenase in the Retina of Drosophila melanogaster. Damulewicz M, et al. Mol Neurobiol, 2017 Sep. PMID 27520276, Free PMC Article
  5. Reciprocal regulation of carbon monoxide metabolism and the circadian clock. Klemz R, et al. Nat Struct Mol Biol, 2017 Jan. PMID 27892932

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HO can be tightly regulated at developmental stages and the relevant expression is necessary for the normal development of tissues in Drosophila.
    Title: Relevant expression of Drosophila heme oxygenase is necessary for the normal development of insect tissues.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme oxygenase (decyclizing) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme oxygenase (decyclizing) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heme metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heme oxidation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 

General protein information

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Preferred Names
heme oxygenase
Names
CG14716-PA
Ho-PA
haem oxygenase
NP_524321.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11679743..11680976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079597.3 → NP_524321.1  heme oxygenase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524321.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VGJ9
    Related
    FBpp0081900
    Conserved Domains (1) summary
    pfam01126
    Location:25 → 265
    Heme_oxygenase; Heme oxygenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VGJ9 Q9VGJ9

Gene LinkOut

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