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Dtd D-aminoacyl-tRNA deacylase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41371, updated on 4-Jan-2025

Summary

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Official Symbol
Dtdprovided by FlyBase
Official Full Name
D-aminoacyl-tRNA deacylaseprovided by FlyBase
Primary source
FLYBASE:FBgn0037898
Locus tag
Dmel_CG18643
See related
AllianceGenome:FB:FBgn0037898
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18643; DmDTD; Dmel\CG18643; DTD
Summary
Enables Gly-tRNA(Ala) hydrolase activity. Predicted to be involved in tRNA metabolic process. Predicted to be active in cytoplasm. Orthologous to human DTD1 (D-aminoacyl-tRNA deacylase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Dtd in Genome Data Viewer
Location:
86E5-86E5; 3-51 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11430061..11430762)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7255783..7256484)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ninaG Neighboring gene Spastizin Neighboring gene Ribosomal protein L24-like Neighboring gene uncharacterized protein Neighboring gene Exonuclease 3'-5' domain-containing 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Elongation Factor Tu Prevents Misediting of Gly-tRNA(Gly) Caused by the Design Behind the Chiral Proofreading Site of D-Aminoacyl-tRNA Deacylase. Routh SB, et al. PLoS Biol, 2016 May. PMID 27224426, Free PMC Article
  2. Role of D-aminoacyl-tRNA deacylase beyond chiral proofreading as a cellular defense against glycine mischarging by AlaRS. Pawar KI, et al. Elife, 2017 Mar 31. PMID 28362257, Free PMC Article
  3. Analysis of the Otd-dependent transcriptome supports the evolutionary conservation of CRX/OTX/OTD functions in flies and vertebrates. Ranade SS, et al. Dev Biol, 2008 Mar 15. PMID 18241855, Free PMC Article
  4. Ultra-deep sequencing of ribosome-associated poly-adenylated RNA in early Drosophila embryos reveals hundreds of conserved translated sORFs. Li H, et al. DNA Res, 2016 Dec. PMID 27559081, Free PMC Article
  5. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables D-aminoacyl-tRNA deacylase activity IEA
Inferred from Electronic Annotation
more info
  
enables D-tyrosyl-tRNA(Tyr) deacylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Gly-tRNA(Ala) hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
D-aminoacyl-tRNA deacylase
Names
CG18643-PB
CG18643-PC
Dtd-PB
Dtd-PC
NP_001287286.1
NP_650072.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11430061..11430762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300357.1 → NP_001287286.1  D-aminoacyl-tRNA deacylase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287286.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LH54
    Conserved Domains (1) summary
    cl00253
    Location:2 → 45
    Dtyr_deacylase; D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not ...

  2. NM_141815.2 → NP_650072.2  D-aminoacyl-tRNA deacylase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650072.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q4V4U7, Q4V6L2, Q9VGP0
    Conserved Domains (1) summary
    pfam02580
    Location:2 → 145
    Tyr_Deacylase; D-Tyr-tRNA(Tyr) deacylase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LH54 A0A0B4LH54
Q9VGP0.2 Q9VGP0

Gene LinkOut

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