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Sptz Spastizin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41370, updated on 9-Dec-2024

Summary

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Official Symbol
Sptzprovided by FlyBase
Official Full Name
Spastizinprovided by FlyBase
Primary source
FLYBASE:FBgn0037897
Locus tag
Dmel_CG5270
See related
AllianceGenome:FB:FBgn0037897
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5270; D-Sptz; Dmel\CG5270; sptz
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Involved in autophagy. Predicted to be active in centrosome and midbody. Is expressed in several structures, including adult midgut progenitor cell; amnioserosa; embryonic/larval midgut; spermatozoon; and yolk nucleus. Used to study hereditary spastic paraplegia 15. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 15. Orthologous to human ZFYVE26 (zinc finger FYVE-type containing 26). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Sptz in Genome Data Viewer
Location:
86E5-86E5; 3-51 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11422092..11429969)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7247814..7255691)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ninaG Neighboring gene Ribosomal protein L24-like Neighboring gene D-aminoacyl-tRNA deacylase Neighboring gene uncharacterized protein Neighboring gene Exonuclease 3'-5' domain-containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rescue of lysosomal function as therapeutic strategy for SPG15 hereditary spastic paraplegia. Vantaggiato C, et al. Brain, 2023 Mar 1. PMID 36029068, Free PMC Article
  2. Comparative exploration of mammalian deafness gene homologues in the Drosophila auditory organ shows genetic correlation between insect and vertebrate hearing. Sutton DC, et al. PLoS One, 2024. PMID 38412189, Free PMC Article
  3. Toward a comprehensive map of the effectors of rab GTPases. Gillingham AK, et al. Dev Cell, 2014 Nov 10. PMID 25453831, Free PMC Article
  4. Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. Lowe N, et al. Development, 2014 Oct. PMID 25294943, Free PMC Article
  5. In vivo analysis of proteomes and interactomes using Parallel Affinity Capture (iPAC) coupled to mass spectrometry. Rees JS, et al. Mol Cell Proteomics, 2011 Jun. PMID 21447707, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cytokinesis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
spastizin
Names
CG5270-PB
D-Spastizin
Sptz-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11422092..11429969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169389.3 → NP_731570.2  spastizin [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731570.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86NZ0, Q961I5, Q9VGP1
    Related
    FBpp0081863
    Conserved Domains (1) summary
    cl22851
    Location:1441 → 1500
    PHD_SF; PHD finger superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VGP1.3 Q9VGP1

Gene LinkOut

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