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CG5214 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41360, updated on 9-Dec-2024

Summary

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Official Symbol
CG5214provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037891
Locus tag
Dmel_CG5214
See related
AllianceGenome:FB:FBgn0037891
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
alpha-KGDHC; Dmel\CG5214; GM01350p; Q9VGQ1
Summary
Predicted to enable dihydrolipoyllysine-residue succinyltransferase activity. Involved in cellular respiration. Located in Z disc. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG5214 in Genome Data Viewer
Location:
86D9-86D9; 3-50 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11244302..11246862)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7070024..7072584)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene SCP-containing protein A Neighboring gene uncharacterized protein Neighboring gene cherub Neighboring gene long non-coding RNA:CR31386

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial Dynamics in the Drosophila Ovary Regulates Germ Stem Cell Number, Cell Fate, and Female Fertility. Garcez M, et al. Front Cell Dev Biol, 2020. PMID 33585443, Free PMC Article
  2. A modular toolset of phiC31-based fluorescent protein tagging vectors for Drosophila. Luo J, et al. Fly (Austin), 2019 Mar-Dec. PMID 30885036, Free PMC Article
  3. Genomic imprinting absent in Drosophila melanogaster adult females. Coolon JD, et al. Cell Rep, 2012 Jul 26. PMID 22840398, Free PMC Article
  4. The alpha-ketoacid dehydrogenase complexes of Drosophila melanogaster. Marygold SJ. MicroPubl Biol, 2024. PMID 38741935, Free PMC Article
  5. The oxoglutarate dehydrogenase complex is involved in myofibril growth and Z-disc assembly in Drosophila. González Morales N, et al. J Cell Sci, 2023 Jul 1. PMID 37272588, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables dihydrolipoyllysine-residue succinyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydrolipoyllysine-residue succinyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydrolipoyllysine-residue succinyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to oxoglutarate dehydrogenase (NAD+) activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tricarboxylic acid cycle TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of oxoadipate dehydrogenase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of oxoglutarate dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
  
part_of oxoglutarate dehydrogenase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of oxoglutarate dehydrogenase complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG5214-PA
NP_650064.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11244302..11246862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141807.2 → NP_650064.1  uncharacterized protein Dmel_CG5214 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650064.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VGQ1
    Related
    FBpp0081834
    Conserved Domains (3) summary
    cd06849
    Location:77 → 149
    lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
    TIGR01347
    Location:78 → 468
    sucB; 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component)
    pfam00198
    Location:255 → 462
    2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VGQ1 Q9VGQ1

Gene LinkOut

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