SdhC Succinate dehydrogenase, subunit C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: SdhCprovided by FlyBase
Official Full Name: Succinate dehydrogenase, subunit Cprovided by FlyBase
Primary source: FLYBASE:FBgn0037873
Locus tag: Dmel_CG6666
See related: AllianceGenome:FB:FBgn0037873
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RH04289; C560; CG6666; Dmel\CG6666; RH04289p; SDH; SDH-C; sdhC; Sdhc; SDHC
Summary: Predicted to enable electron transfer activity. Involved in determination of adult lifespan; mitochondrial electron transport, succinate to ubiquinone; and response to oxidative stress. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Is expressed in several structures, including Malpighian tubule primordium; adult head; adult heart; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; lung non-small cell carcinoma; and paraganglioma. Orthologous to human SDHC (succinate dehydrogenase complex subunit C). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 86D7-86D8; 3-50 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (11208887..11209849, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (7034609..7035571, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables electron transfer activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial electron transport, succinate to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, succinate to ubiquinone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of respiratory chain complex II (succinate dehydrogenase)	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex II (succinate dehydrogenase)	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: succinate dehydrogenase, subunit C

Names: CG6666-PA; CG6666-PB; SdhC-PA; SdhC-PB; succinate dehydrogenase; succinate dehydrogenase C; succinate dehydrogenase cytochrome B560; succinate dehydrogenase cytochrome B560 subunit

NP_001262472.1

EC 1.3.-.-

NP_650047.3

EC 1.3.-.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

11208887..11209849 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001275543.1 → NP_001262472.1 succinate dehydrogenase, subunit C, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262472.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MYW1, Q8SY80, Q9VGS3

Conserved Domains (1) summary

cd03499
Location:52 → 170

SQR_TypeC_SdhC; Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the ...
NM_141790.3 → NP_650047.3 succinate dehydrogenase, subunit C, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650047.3

Status: REVIEWED

UniProtKB/TrEMBL

Q8MYW1, Q8SY80, Q9VGS3

Related

FBpp0081848

Conserved Domains (1) summary

cd03499
Location:52 → 170

SQR_TypeC_SdhC; Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the ...