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Tengl4 Testis EndoG-Like 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41321, updated on 4-Jan-2025

Summary

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Official Symbol
Tengl4provided by FlyBase
Official Full Name
Testis EndoG-Like 4provided by FlyBase
Primary source
FLYBASE:FBgn0037857
Locus tag
Dmel_CG4683
See related
AllianceGenome:FB:FBgn0037857
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4683; Dmel\CG4683
Summary
Predicted to enable RNA endonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be active in mitochondrial inner membrane and nucleus. Orthologous to human ENDOG (endonuclease G). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Tengl4 in Genome Data Viewer
Location:
86C12-86C13; 3-50 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10950284..10951797)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6776006..6777519)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45577 Neighboring gene long non-coding RNA:CR45578 Neighboring gene long non-coding RNA:CR45561 Neighboring gene sidestep VI Neighboring gene long non-coding RNA:CR46007

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Barriers to male transmission of mitochondrial DNA in sperm development. DeLuca SZ, et al. Dev Cell, 2012 Mar 13. PMID 22421049, Free PMC Article
  2. Deficiency of ValRS-m Causes Male Infertility in Drosophila melanogaster. Duan X, et al. Int J Mol Sci, 2024 Jul 8. PMID 39000597, Free PMC Article
  3. SCORE: a computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data. Site clustering over random expectation. Rebeiz M, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12107285, Free PMC Article
  4. Molecular definitions of autophagy and related processes. Galluzzi L, et al. EMBO J, 2017 Jul 3. PMID 28596378, Free PMC Article
  5. Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster. Weber AL, et al. PLoS One, 2012. PMID 22496853, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA endodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
testis EndoG-Like 4
Names
CG4683-PA
Tengl4-PA
NP_650038.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    10950284..10951797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141781.2 → NP_650038.2  testis EndoG-Like 4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650038.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VGU3
    Related
    FBpp0081802
    Conserved Domains (1) summary
    pfam01223
    Location:132 → 362
    Endonuclease_NS; DNA/RNA non-specific endonuclease
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VGU3 Q9VGU3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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