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Sodh2 Sorbitol dehydrogenase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41313, updated on 4-Jan-2025

Summary

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Official Symbol
Sodh2provided by FlyBase
Official Full Name
Sorbitol dehydrogenase 2provided by FlyBase
Primary source
FLYBASE:FBgn0022359
Locus tag
Dmel_CG4649
See related
AllianceGenome:FB:FBgn0022359
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4649; Dmel\CG4649; DM_7299382; Sdh; Sdh-2; Sodh-2; SODH-2
Summary
Enables L-iditol 2-dehydrogenase (NAD+) activity. Involved in fructose biosynthetic process and sorbitol catabolic process. Predicted to be active in cytosol. Is expressed in adult head; amnioserosa; embryonic/larval midgut; organism; and yolk nucleus. Used to study autosomal recessive distal hereditary motor neuronopathy 8. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 8. Orthologous to human SORD (sorbitol dehydrogenase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Sodh2 in Genome Data Viewer
Location:
86C7-86C7; 3-50 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10876384..10878257)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6702106..6703979)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Formaldehyde dehydrogenase Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45195 Neighboring gene uncharacterized protein Neighboring gene Thiamine pyrophosphate carrier protein 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sorbitol reduction via govorestat ameliorates synaptic dysfunction and neurodegeneration in sorbitol dehydrogenase deficiency. Zhu Y, et al. JCI Insight, 2023 May 22. PMID 37014713, Free PMC Article
  2. Sorbitol dehydrogenase of Drosophila. Gene, protein, and expression data show a two-gene system. Luque T, et al. J Biol Chem, 1998 Dec 18. PMID 9852094
  3. Biallelic mutations in SORD cause a common and potentially treatable hereditary neuropathy with implications for diabetes. Cortese A, et al. Nat Genet, 2020 May. PMID 32367058, Free PMC Article
  4. Drosophila TRF2 is a preferential core promoter regulator. Kedmi A, et al. Genes Dev, 2014 Oct 1. PMID 25223897, Free PMC Article
  5. The polyol pathway is an evolutionarily conserved system for sensing glucose uptake. Sano H, et al. PLoS Biol, 2022 Jun. PMID 35687590, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-iditol 2-dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-iditol 2-dehydrogenase (NAD+) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables L-iditol 2-dehydrogenase (NAD+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables L-iditol 2-dehydrogenase (NAD+) activity TAS
Traceable Author Statement
more info
 PubMed 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fructose biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sorbitol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sorbitol catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sorbitol catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
sorbitol dehydrogenase 2
Names
CG4649-PA
Sodh2-PA
sorbitol dehydrogenase
sorbitol dehydrogenase-2
NP_524311.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    10876384..10878257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079587.3 → NP_524311.1  sorbitol dehydrogenase 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524311.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O96299, Q960H1
    Related
    FBpp0081800
    Conserved Domains (2) summary
    cd05285
    Location:8 → 349
    sorbitol_DH; Sorbitol dehydrogenase
    PLN02702
    Location:4 → 346
    PLN02702; L-idonate 5-dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O96299 O96299

Gene LinkOut

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