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Cad86C Cadherin 86C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41302, updated on 4-Jan-2025

Summary

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Official Symbol
Cad86Cprovided by FlyBase
Official Full Name
Cadherin 86Cprovided by FlyBase
Primary source
FLYBASE:FBgn0261053
Locus tag
Dmel_CG42601
See related
AllianceGenome:FB:FBgn0261053
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LP07955; CG31393; CG31425; CG33112; CG42601; CG4509; CG4655; CT14654; CT15041; DCad86C; Dmel\CG42601
Old locus tag
Dmel_CG4509; Dmel_CG4655
Summary
Predicted to enable calcium ion binding activity. Involved in regulation of cell shape. Part of subapical complex. Is expressed in several structures, including eye disc morphogenetic furrow; eye disc posterior to the morphogenetic furrow; main body follicle cell; spermatozoon; and stigmatophore. Human ortholog(s) of this gene implicated in cone-rod dystrophy 15. Orthologous to human CDHR1 (cadherin related family member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Cad86C in Genome Data Viewer
Location:
86C7-86C7; 3-50 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10827079..10849030)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6652801..6674752)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tubulin tyrosine ligase-like 15 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hedgehog morphogen gradient is robust towards variations in tissue morphology in Drosophila. Pierini G, et al. Sci Rep, 2023 May 25. PMID 37231029, Free PMC Article
  2. Hedgehog and Dpp signaling induce cadherin Cad86C expression in the morphogenetic furrow during Drosophila eye development. Schlichting K, et al. Mech Dev, 2008 Aug. PMID 18539010
  3. Drosophila eye size is determined by Innexin 2-dependent Decapentaplegic signalling. Richard M, et al. Dev Biol, 2015 Dec 1. PMID 26455410
  4. Co-option of an Ancestral Hox-Regulated Network Underlies a Recently Evolved Morphological Novelty. Glassford WJ, et al. Dev Cell, 2015 Sep 14. PMID 26343453, Free PMC Article
  5. Cadherins in embryonic and neural morphogenesis. Tepass U, et al. Nat Rev Mol Cell Biol, 2000 Nov. PMID 11253370

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion mediated by cadherin ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of subapical complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cadherin 86C
Names
CG42601-PC
CG42601-PD
CG42601-PE
CG42601-PF
CG42601-PG
Cad86C-PC
Cad86C-PD
Cad86C-PE
Cad86C-PF
Cad86C-PG
cadherin Cad86C

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    10827079..10849030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176458.4 → NP_788635.3  cadherin 86C, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788635.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B3GN10, Q8MZ37, Q9VGW1
    UniProtKB/TrEMBL
    A0A0B4K655
    Conserved Domains (1) summary
    cd11304
    Location:605 → 703
    Cadherin_repeat; Cadherin tandem repeat domain

  2. NM_001260105.1 → NP_001247034.1  cadherin 86C, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247034.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6P8
    Conserved Domains (1) summary
    cd11304
    Location:605 → 703
    Cadherin_repeat; Cadherin tandem repeat domain

  3. NM_001260104.1 → NP_001247033.1  cadherin 86C, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247033.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B3GN10, Q8MZ37, Q9VGW1
    UniProtKB/TrEMBL
    A0A0B4K6E3
    Conserved Domains (1) summary
    cd11304
    Location:605 → 703
    Cadherin_repeat; Cadherin tandem repeat domain

  4. NM_001260102.1 → NP_001247031.1  cadherin 86C, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247031.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B3GN10, Q8MZ37, Q9VGW1
    UniProtKB/TrEMBL
    A0A0B4K655
    Conserved Domains (1) summary
    cd11304
    Location:605 → 703
    Cadherin_repeat; Cadherin tandem repeat domain

  5. NM_001260103.1 → NP_001247032.1  cadherin 86C, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247032.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B3GN10, Q8MZ37, Q9VGW1
    UniProtKB/TrEMBL
    A0A0B4K720
    Conserved Domains (2) summary
    cd11304
    Location:577 → 675
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:260 → 336
    CA; Cadherin repeats
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K655 A0A0B4K655
A0A0B4K6E3 A0A0B4K6E3
A0A0B4K6P8 A0A0B4K6P8
A0A0B4K720 A0A0B4K720
Q95SX1 Q95SX1
Q9VGW1.3 Q9VGW1

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