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hth - homothorax

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; protein heterodimerization activity; and transcription coactivator binding activity. Involved in several processes, including imaginal disc-derived appendage morphogenesis; nervous system development; and positive regulation of cell proliferation involved in compound eye morphogenesis. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex and protein-DNA complex. Is expressed in several structures, including germ layer; imaginal disc; organism subdivision; segmental subdivision of organ system; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in cleft palate; cleft palate, cardiac defects, and intellectual disabillity; learning disability; open-angle glaucoma; and orofacial cleft. Orthologous to several human genes including MEIS1 (Meis homeobox 1) and MEIS3 (Meis homeobox 3). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa