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Rrp46 Rrp46 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41270, updated on 9-Dec-2024

Summary

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Official Symbol
Rrp46provided by FlyBase
Official Full Name
Rrp46provided by FlyBase
Primary source
FLYBASE:FBgn0037815
Locus tag
Dmel_CG4043
See related
AllianceGenome:FB:FBgn0037815
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4043; Dmel\CG4043; dRrp46; rrp46
Summary
Predicted to enable RNA binding activity. Involved in regulation of gene expression. Located in cytoplasm. Part of nuclear exosome (RNase complex). Orthologous to human EXOSC5 (exosome component 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Rrp46 in Genome Data Viewer
Location:
86B4-86B4; 3-49 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10413301..10414242)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6239023..6239964)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mir-318 stem loop Neighboring gene Iron regulatory protein 1B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 12e1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dis3- and exosome subunit-responsive 3' mRNA instability elements. Kiss DL, et al. Biochem Biophys Res Commun, 2012 Jul 6. PMID 22668878, Free PMC Article
  2. Differential distribution of exosome subunits at the nuclear lamina and in cytoplasmic foci. Graham AC, et al. Mol Biol Cell, 2006 Mar. PMID 16407406, Free PMC Article
  3. Genome-wide analysis reveals distinct substrate specificities of Rrp6, Dis3, and core exosome subunits. Kiss DL, et al. RNA, 2010 Apr. PMID 20185544, Free PMC Article
  4. Drosophila melanogaster Dis3 N-terminal domains are required for ribonuclease activities, nuclear localization and exosome interactions. Mamolen M, et al. Nucleic Acids Res, 2010 Sep. PMID 20421210, Free PMC Article
  5. An efficient protein complex purification method for functional proteomics in higher eukaryotes. Forler D, et al. Nat Biotechnol, 2003 Jan. PMID 12483225

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in U4 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear mRNA surveillance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in poly(A)-dependent snoRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exosome (RNase complex) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear exosome (RNase complex) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear exosome (RNase complex) ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rrp46
Names
CG4043-PA
Rrp46-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    10413301..10414242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141744.3 → NP_650001.2  Rrp46 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650001.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TW1, Q9VGZ2
    Related
    FBpp0081725
    Conserved Domains (2) summary
    cd11372
    Location:14 → 211
    RNase_PH_RRP46; RRP46 subunit of eukaryotic exosome
    COG0689
    Location:10 → 215
    Rph; Ribonuclease PH [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95TW1 Q95TW1
Q9VGZ2 Q9VGZ2

Gene LinkOut

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