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CAH7 Carbonic anhydrase 7 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41238, updated on 9-Dec-2024

Summary

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Official Symbol
CAH7provided by FlyBase
Official Full Name
Carbonic anhydrase 7provided by FlyBase
Primary source
FLYBASE:FBgn0037788
Locus tag
Dmel_CG3940
See related
AllianceGenome:FB:FBgn0037788
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3940; Dmel\CG3940
Summary
Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in cytoplasm. Is expressed in adult head; adult heart; cuboidal/columnar epithelium; embryonic/larval midgut; and gastric caecum. Human ortholog(s) of this gene implicated in isolated hyperchlorhidrosis and lung non-small cell carcinoma. Orthologous to human CA12 (carbonic anhydrase 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CAH7 in Genome Data Viewer
Location:
85F12-85F13; 3-49 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10112237..10120081)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5937959..5945803)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43459 Neighboring gene mir-34 stem loop Neighboring gene Fragile X messenger ribonucleoprotein 1 Neighboring gene ATP synthase, epsilon subunit-like Neighboring gene gamma Soluble NSF attachment protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest. Dockendorff TC, et al. Neuron, 2002 Jun 13. PMID 12086644
  2. Carbonic anhydrases and anion transport in mosquito midgut pH regulation. Linser PJ, et al. J Exp Biol, 2009 Jun. PMID 19448076, Free PMC Article
  3. Molecular mechanism and functional significance of acid generation in the Drosophila midgut. Overend G, et al. Sci Rep, 2016 Jun 2. PMID 27250760, Free PMC Article
  4. Meta-Analysis of Grainyhead-Like Dependent Transcriptional Networks: A Roadmap for Identifying Novel Conserved Genetic Pathways. Mathiyalagan N, et al. Genes (Basel), 2019 Oct 31. PMID 31683705, Free PMC Article
  5. Regulation of the BMP Signaling-Responsive Transcriptional Network in the Drosophila Embryo. Deignan L, et al. PLoS Genet, 2016 Jul. PMID 27379389, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables carbonate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbonate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carbonic anhydrase 7
Names
CAH7-PA
CAH7-PB
CAH7-PC
CG3940-PA
CG3940-PB
CG3940-PC
NP_001287267.1
NP_001287268.1
NP_649979.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    10112237..10120081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300338.1 → NP_001287267.1  carbonic anhydrase 7, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287267.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VH26
    Conserved Domains (1) summary
    cd00326
    Location:45 → 269
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

  2. NM_001300339.1 → NP_001287268.1  carbonic anhydrase 7, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287268.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VH26
    Conserved Domains (1) summary
    cd00326
    Location:45 → 269
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

  3. NM_141722.2 → NP_649979.1  carbonic anhydrase 7, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649979.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VH26
    Related
    FBpp0081657
    Conserved Domains (1) summary
    cd00326
    Location:45 → 269
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MS01 Q8MS01
Q9VH26 Q9VH26

Gene LinkOut

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