eca eclair [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ecaprovided by FlyBase
Official Full Name: eclairprovided by FlyBase
Primary source: FLYBASE:FBgn0069242
Locus tag: Dmel_CG33104
See related: AllianceGenome:FB:FBgn0069242
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG33104; CG9443; Dmel\CG33104; Eca; ECA; p24
Summary: Predicted to enable cargo receptor activity. Involved in dorsal/ventral pattern formation; endoplasmic reticulum to Golgi vesicle-mediated transport; and wing disc development. Located in endomembrane system. Is expressed in several structures, including adult brain; adult head; adult ventral nerve cord; fat body; and gland. Orthologous to several human genes including TMED4 (transmembrane p24 trafficking protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (9684469..9685476, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (5510191..5511198, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Emp24 and Eca act as specific cargo receptors for Wg to concentrate it in forming vesicles at sites of endoplasmic reticulum export.
Title: A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion.
Mutations in either eca or bai are sufficient for the depletion of Tkv activity.
Title: Drosophila p24 homologues eclair and baiser are necessary for the activity of the maternally expressed Tkv receptor during early embryogenesis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cargo receptor activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi vesicle transport	ISM Inferred from Sequence Model more info	PubMed
involved_in dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in COPII-coated ER to Golgi transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in endomembrane system	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum-Golgi intermediate compartment	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed