Dh44 Diuretic hormone 44 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dh44provided by FlyBase
Official Full Name: Diuretic hormone 44provided by FlyBase
Primary source: FLYBASE:FBgn0012344
Locus tag: Dmel_CG8348
See related: AllianceGenome:FB:FBgn0012344
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8348; CRF; Dh; DH; DH 44; DH-44; DH44; DH[[44]]; Dmel\CG8348; Drm-DH; drome-DH44; Drome-DH[[44]]
Summary: Enables G protein-coupled receptor binding activity. Involved in several processes, including behavioral response to pain; body fluid secretion; and locomotor rhythm. Predicted to be located in extracellular space. Is expressed in several structures, including adult brain; embryonic anterior abdominal segment; neurosecretory neurons; synaptic neuropil domain; and synaptic neuropil subdomain. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (9638182..9650706)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (5463904..5476428)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Food ingestion in Drosophila is diminished by knockdown of DH44, but not LK, and water retention is increased by LK knockdown only.
Title: Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila.
DH44 Kinin neuropeptide modulates desiccation and starvation tolerance in Drosophila melanogaster.
Title: The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster.
The Dh44/DH44 receptor system directs the detection and consumption of nutritive sugars through a positive feedback loop.
Title: Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila.
not upregulated by cold exposure
Title: A comparison of Frost expression among species and life stages of Drosophila.
Results describe Dh, the gene that encodes a CRF-like peptide (Drome-DH(44)) in Drosophila melanogaster.
Title: The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP.

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Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables diuretic hormone activity	NAS Non-traceable Author Statement more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in behavioral response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in body fluid secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in hormone-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IC Inferred by Curator more info	PubMed

Names: CG8348-PA; CG8348-PC; CRF-like diuretic hormone; CRF-like peptide; Dh44-PA; Dh44-PC; diuretic hormone

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The following sections contain reference sequences that belong to a specific genome build. Explain