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Vps45 Vacuolar protein sorting 45 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41153, updated on 9-Dec-2024

Summary

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Official Symbol
Vps45provided by FlyBase
Official Full Name
Vacuolar protein sorting 45provided by FlyBase
Primary source
FLYBASE:FBgn0261049
Locus tag
Dmel_CG8228
See related
AllianceGenome:FB:FBgn0261049
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8228; Dmel\CG8228; DmVps45; dVps45; MENE (3R)-C; MENE(3R)-C; vps45; VPS45; Vps45p
Summary
Enables SNARE binding activity. Involved in endocytosis; endosomal vesicle fusion; and plasma membrane to endosome transport. Located in early endosome. Is expressed in adult head; organism; and spermatozoon. Human ortholog(s) of this gene implicated in severe congenital neutropenia 5. Orthologous to human VPS45 (vacuolar protein sorting 45 homolog). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Vps45 in Genome Data Viewer
Location:
85D25-85D25; 3-48 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9563924..9566092)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5389646..5391814)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Methyl-CpG binding domain protein-like Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vesicle trafficking: pleasure and pain from SM genes. Toonen RF, et al. Trends Cell Biol, 2003 Apr. PMID 12667755
  2. Drosophila Strip serves as a platform for early endosome organization during axon elongation. Sakuma C, et al. Nat Commun, 2014 Oct 14. PMID 25312435, Free PMC Article
  3. Tethering complexes in the endocytic pathway: CORVET and HOPS. Solinger JA, et al. FEBS J, 2013 Jun. PMID 23351085
  4. Seamless tube shape is constrained by endocytosis-dependent regulation of active Moesin. Schottenfeld-Roames J, et al. Curr Biol, 2014 Aug 4. PMID 25065756, Free PMC Article
  5. Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosyn and Vps45. Morrison HA, et al. Mol Biol Cell, 2008 Oct. PMID 18685079, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables SNARE binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables SNARE binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endosomal vesicle fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurotransmitter secretion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in plasma membrane to endosome transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle priming NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
vacuolar protein sorting 45
Names
CG8228-PA
Vps45-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9563924..9566092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141652.2 → NP_649909.1  vacuolar protein sorting 45 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649909.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VHB5
    Related
    FBpp0081548
    Conserved Domains (1) summary
    pfam00995
    Location:23 → 543
    Sec1; Sec1 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VHB5 Q9VHB5

Gene LinkOut

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