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Task7 TWIK-related acid-sensitive K[+] channel 7 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41125, updated on 4-Jan-2025

Summary

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Official Symbol
Task7provided by FlyBase
Official Full Name
TWIK-related acid-sensitive K[+] channel 7provided by FlyBase
Primary source
FLYBASE:FBgn0037690
Locus tag
Dmel_CG9361
See related
AllianceGenome:FB:FBgn0037690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9361; Dmel\CG9361; dmTASK7; dTASK-7; K2P-TASK7; TASK-7
Summary
Enables potassium channel activity and protein heterodimerization activity. Involved in potassium ion transmembrane transport. Located in membrane. Is expressed in several structures, including adult brain cell body rind; anterior-posterior subdivision of organism; and cell body rind of adult antennal lobe. Human ortholog(s) of this gene implicated in Birk-Barel syndrome and primary pulmonary hypertension. Orthologous to several human genes including KCNK9 (potassium two pore domain channel subfamily K member 9). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Task7 in Genome Data Viewer
Location:
85D15-85D15; 3-48 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9410329..9412293, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5236051..5238015, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene BBSome interacting protein 1 Neighboring gene beta-Tubulin at 85D Neighboring gene uncharacterized protein Neighboring gene alpha-Mannosidase class II a Neighboring gene pasilla

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hormonal control of motivational circuitry orchestrates the transition to sexuality in Drosophila. Zhang SX, et al. Sci Adv, 2021 Jun. PMID 34134981, Free PMC Article
  2. Small conductance Ca(2+)-activated K(+) channels induce the firing pause periods during the activation of Drosophila nociceptive neurons. Onodera K, et al. Elife, 2017 Oct 16. PMID 29035200, Free PMC Article
  3. The Cornelia de Lange Syndrome-associated factor NIPBL interacts with BRD4 ET domain for transcription control of a common set of genes. Luna-Peláez N, et al. Cell Death Dis, 2019 Jul 18. PMID 31320616, Free PMC Article
  4. Novel Drosophila two-pore domain K channels: rescue of channel function by heteromeric assembly. Döring F, et al. Eur J Neurosci, 2006 Oct. PMID 17074048
  5. CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A. Ceder MM, et al. Front Cell Dev Biol, 2020. PMID 33163493, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TWIK-related acid-sensitive K[+] channel 7
Names
CG9361-PA
Task7-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9410329..9412293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141634.2 → NP_649891.1  TWIK-related acid-sensitive K[+] channel 7 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649891.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q3ZZY0, Q9VHE0
    Related
    FBpp0081523
    Conserved Domains (1) summary
    pfam07885
    Location:166 → 248
    Ion_trans_2; Ion channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3ZZY0 Q3ZZY0
Q9VHE0 Q9VHE0

Gene LinkOut

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