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drn doctor no [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41114, updated on 9-Dec-2024

Summary

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Official Symbol
drnprovided by FlyBase
Official Full Name
doctor noprovided by FlyBase
Primary source
FLYBASE:FBgn0266410
Locus tag
Dmel_CG45050
See related
AllianceGenome:FB:FBgn0266410
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-85Da; anon-EST:fe1B11; anon-EST:fe2G11; BcDNA:RE70963; CG16750; CG16751; CG30492; CG33187; CG33188; CG33936; CG33937; CG43674; CG45050; Dmel\CG45050
Old locus tag
Dmel_CG33937; Dmel_CG43674
Summary
Predicted to enable polyubiquitin modification-dependent protein binding activity. Involved in determination of digestive tract left/right asymmetry and positive regulation of receptor signaling pathway via JAK-STAT. Is active in cytoplasm. Is expressed in organism; spermatozoon; and wing disc. Orthologous to human ZFAND5 (zinc finger AN1-type containing 5) and ZFAND6 (zinc finger AN1-type containing 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See drn in Genome Data Viewer
Location:
85D11-85D11; 3-48 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9340216..9362994)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5165938..5188716)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43301 Neighboring gene pasiflora 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Serine racemase Neighboring gene FER tyrosine kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila AWP1 ortholog Doctor No regulates JAK/STAT signaling for left-right asymmetry in the gut by promoting receptor endocytosis. Lai YT, et al. Development, 2023 Mar 15. PMID 36861793, Free PMC Article
  2. Molecular and genetic organization of Drosophila melanogaster polytene chromosomes: evidence for two types of interband regions. Demakov S, et al. Genetica, 2004 Nov. PMID 15609554
  3. A piggyBac transposon gene trap for the analysis of gene expression and function in Drosophila. Bonin CP, et al. Genetics, 2004 Aug. PMID 15342518, Free PMC Article
  4. The Fes/Fer non-receptor tyrosine kinase cooperates with Src42A to regulate dorsal closure in Drosophila. Murray MJ, et al. Development, 2006 Aug. PMID 16831834
  5. Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution. Lu TC, et al. Science, 2023 Jun 16. PMID 37319212, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 9361869-9362054 mobile_element_type = transposon:pogo{}1279

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables polyubiquitin modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in determination of digestive tract left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
doctor no
Names
CG45050-PB
CG45050-PC
CG45050-PD
CG45050-PE
CG45050-PF
CG45050-PG
CG45050-PH
CG45050-PI
anon-fast-evolving-1B11
anon-fast-evolving-2G11
drn-PB
drn-PC
drn-PD
drn-PE
drn-PF
drn-PG
drn-PH
drn-PI

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9340216..9362994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001031991.3 → NP_001027162.1  doctor no, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027162.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WQ62, Q9VHF4
    Conserved Domains (3) summary
    smart00154
    Location:140 → 177
    ZnF_AN1; AN1-like Zinc finger
    TIGR00601
    Location:37 → 120
    rad23; UV excision repair protein Rad23
    pfam01754
    Location:11 → 32
    zf-A20; A20-like zinc finger

  2. NM_001275480.2 → NP_001262409.1  doctor no, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262409.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WQ62, Q9VHF4
    Conserved Domains (3) summary
    smart00154
    Location:140 → 177
    ZnF_AN1; AN1-like Zinc finger
    TIGR00601
    Location:37 → 120
    rad23; UV excision repair protein Rad23
    pfam01754
    Location:11 → 32
    zf-A20; A20-like zinc finger

  3. NM_001300317.1 → NP_001287246.1  doctor no, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287246.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WQ62, Q9VHF4
    Conserved Domains (3) summary
    smart00154
    Location:140 → 177
    ZnF_AN1; AN1-like Zinc finger
    TIGR00601
    Location:37 → 120
    rad23; UV excision repair protein Rad23
    pfam01754
    Location:11 → 32
    zf-A20; A20-like zinc finger

  4. NM_001275478.2 → NP_001262407.1  doctor no, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262407.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WQ62, Q9VHF4
    Conserved Domains (3) summary
    smart00154
    Location:140 → 177
    ZnF_AN1; AN1-like Zinc finger
    TIGR00601
    Location:37 → 120
    rad23; UV excision repair protein Rad23
    pfam01754
    Location:11 → 32
    zf-A20; A20-like zinc finger

  5. NM_001275479.2 → NP_001262408.1  doctor no, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262408.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WQ62, Q9VHF4
    Conserved Domains (3) summary
    smart00154
    Location:140 → 177
    ZnF_AN1; AN1-like Zinc finger
    TIGR00601
    Location:37 → 120
    rad23; UV excision repair protein Rad23
    pfam01754
    Location:11 → 32
    zf-A20; A20-like zinc finger

  6. NM_001031990.4 → NP_001027161.1  doctor no, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027161.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WQ62, Q9VHF4
    Conserved Domains (3) summary
    smart00154
    Location:140 → 177
    ZnF_AN1; AN1-like Zinc finger
    TIGR00601
    Location:37 → 120
    rad23; UV excision repair protein Rad23
    pfam01754
    Location:11 → 32
    zf-A20; A20-like zinc finger

  7. NM_001275481.2 → NP_001262410.2  doctor no, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262410.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGY1
    Conserved Domains (1) summary
    smart00154
    Location:124 → 161
    ZnF_AN1; AN1-like Zinc finger

  8. NM_001300318.1 → NP_001287247.1  doctor no, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287247.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGY1
    Conserved Domains (1) summary
    smart00154
    Location:124 → 161
    ZnF_AN1; AN1-like Zinc finger
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGY1 A0A0B4KGY1
Q8T3W4 Q8T3W4
Q9VHF4 Q9VHF4

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials