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Aduk Another Drosophila Unc-51-like kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41112, updated on 9-Dec-2024

Summary

Official Symbol
Adukprovided by FlyBase
Official Full Name
Another Drosophila Unc-51-like kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0037679
Locus tag
Dmel_CG8866
See related
AllianceGenome:FB:FBgn0037679
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ADUK; CG8866; Dmel\CG8866; dULK3; UNC 51-like
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in autophagy and positive regulation of autophagosome assembly. Located in autophagosome. Is expressed in organism. Orthologous to human ULK3 (unc-51 like kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Aduk in Genome Data Viewer
Location:
85D11-85D11; 3-48 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9332064..9334714, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5157786..5160436, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pasiflora 2 Neighboring gene long non-coding RNA:CR43301

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
uncharacterized protein
NP_649882.1
  • another drosophila Unc-51-like kinase, isoform B
NP_731331.1
  • another drosophila Unc-51-like kinase, isoform A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9332064..9334714 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169265.2NP_731331.1  uncharacterized protein Dmel_CG8866 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731331.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86P98, Q9VHF6
    Related
    FBpp0081533
    Conserved Domains (4) summary
    smart00220
    Location:9265
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd02684
    Location:274348
    MIT_2; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.
    pfam04212
    Location:407472
    MIT; MIT (microtubule interacting and transport) domain
    cl21453
    Location:13264
    PKc_like; Protein Kinases, catalytic domain
  2. NM_141625.3NP_649882.1  uncharacterized protein Dmel_CG8866 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649882.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86P98, Q8T0L6
    Related
    FBpp0081534
    Conserved Domains (4) summary
    smart00220
    Location:9265
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd02684
    Location:274348
    MIT_2; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in proteins with an n-terminal serine/threonine kinase domain. The molecular function of the MIT domain is unclear.
    cl00299
    Location:407462
    MIT; MIT: domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
    cl21453
    Location:13264
    PKc_like; Protein Kinases, catalytic domain