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sage salivary gland-expressed bHLH [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41105, updated on 9-Dec-2024

Summary

Official Symbol
sageprovided by FlyBase
Official Full Name
salivary gland-expressed bHLHprovided by FlyBase
Primary source
FLYBASE:FBgn0037672
Locus tag
Dmel_CG12952
See related
AllianceGenome:FB:FBgn0037672
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bHLHc7; CG12952; Dmel\CG12952; Sage
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and salivary gland development. Located in chromatin. Is expressed in adult salivary gland; embryonic primordium of adult salivary gland; embryonic/larval salivary gland; embryonic/larval salivary gland body; and salivary gland body primordium. Human ortholog(s) of this gene implicated in myocardial infarction and spondylocostal dysostosis 2. Orthologous to human MESP1 (mesoderm posterior bHLH transcription factor 1); MESP2 (mesoderm posterior bHLH transcription factor 2); and MSGN1 (mesogenin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See sage in Genome Data Viewer
Location:
85D7-85D7; 3-48 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9262654..9264142, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5088376..5089864, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Insulator binding factor 1 Neighboring gene ATPase H+ transporting accessory protein 2 Neighboring gene Tryptophanyl-tRNA synthetase Neighboring gene Vacuolar protein sorting 16A

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in mesoderm formation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in salivary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
salivary gland-expressed bHLH
Names
CG12952-PA
CG12952-PC
sage-PA
sage-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9262654..9264142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169263.2NP_731326.2  salivary gland-expressed bHLH, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731326.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8INP5, Q9VHG3
    Conserved Domains (1) summary
    pfam00010
    Location:181233
    HLH; Helix-loop-helix DNA-binding domain
  2. NM_079563.3NP_524287.1  salivary gland-expressed bHLH, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524287.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8INP5, Q9VHG3
    Related
    FBpp0081462
    Conserved Domains (1) summary
    pfam00010
    Location:181233
    HLH; Helix-loop-helix DNA-binding domain