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CAHbeta Carbonic anhydrase beta [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41070, updated on 4-Jan-2025

Summary

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Official Symbol
CAHbetaprovided by FlyBase
Official Full Name
Carbonic anhydrase betaprovided by FlyBase
Primary source
FLYBASE:FBgn0037646
Locus tag
Dmel_CG11967
See related
AllianceGenome:FB:FBgn0037646
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BCA; beta-CA; CG11967; DmBCA; DmeCA; Dmel\CG11967; Dmel_CG11967
Summary
Enables carbonate dehydratase activity. Involved in one-carbon metabolic process. Located in mitochondrion. Is expressed in adult heart and organism. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CAHbeta in Genome Data Viewer
Location:
85C1-85C1; 3-48 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8980860..8982793)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4806582..4808515)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Succinyl-coenzyme A synthetase beta subunit, ADP-forming Neighboring gene uncharacterized protein Neighboring gene ichor Neighboring gene Ras-related GTP binding A/B Neighboring gene uncharacterized protein Neighboring gene Enhancer of variegation 3-9 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bortezomib inhibits bacterial and fungal β-carbonic anhydrases. Supuran CT. Bioorg Med Chem, 2016 Sep 15. PMID 27469982
  2. Sulfonamide inhibition studies of the β carbonic anhydrase from Drosophila melanogaster. Syrjänen L, et al. Bioorg Med Chem Lett, 2014 Jul 1. PMID 24852120
  3. β carbonic anhydrase is required for female fertility in Drosophila melanogaster. Syrjänen L, et al. Front Zool, 2015. PMID 26300950, Free PMC Article
  4. Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates. Syrjänen L, et al. BMC Biochem, 2010 Jul 26. PMID 20659325, Free PMC Article
  5. Characterization, bioinformatic analysis and dithiocarbamate inhibition studies of two new α-carbonic anhydrases, CAH1 and CAH2, from the fruit fly Drosophila melanogaster. Syrjänen L, et al. Bioorg Med Chem, 2013 Mar 15. PMID 22989910

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables carbonate dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbonate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in one-carbon metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
carbonic anhydrase beta
Names
CAHbeta-PA
CAHbeta-PB
CG11967-PA
CG11967-PB
GH10821P
beta-carbonic anhydrase
NP_001287242.1
NP_649849.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    8980860..8982793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300313.1 → NP_001287242.1  carbonic anhydrase beta, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287242.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGX6
    Conserved Domains (1) summary
    cl00391
    Location:7 → 59
    beta_CA; Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an ...

  2. NM_141592.3 → NP_649849.1  carbonic anhydrase beta, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649849.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VHJ5
    Related
    FBpp0081438
    Conserved Domains (1) summary
    cd00884
    Location:7 → 228
    beta_CA_cladeB; Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGX6 A0A0B4LGX6
Q8SXB6 Q8SXB6
Q9VHJ5 Q9VHJ5

Gene LinkOut

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