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pyd polychaetoid [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41062, updated on 9-Dec-2024

Summary

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Official Symbol
pydprovided by FlyBase
Official Full Name
polychaetoidprovided by FlyBase
Primary source
FLYBASE:FBgn0262614
Locus tag
Dmel_CG43140
See related
AllianceGenome:FB:FBgn0262614
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11782; CG11962; CG12409; CG31349; CG43140; CG9729; CG9731; CG9763; CT36877; Dmel\CG43140; dzo-1; DZO-1; Pch; Pyd; pyd(Z01); Pyd/ZO-1; tam; Tamou; xvt; ZO-1; ZO1
Old locus tag
Dmel_CG31349; Dmel_CG9731
Summary
Enables cell adhesion molecule binding activity. Involved in several processes, including R8 cell development; embryonic development via the syncytial blastoderm; and open tracheal system development. Located in several cellular components, including adherens junction; basolateral plasma membrane; and nephrocyte diaphragm. Is expressed in several structures, including adult head; epithelium; gut section; mesoderm; and nephrocyte. Human ortholog(s) of this gene implicated in disease of metabolism and progressive familial intrahepatic cholestasis 4. Orthologous to several human genes including TJP2 (tight junction protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See pyd in Genome Data Viewer
Location:
85B2-85B7; 3-48 cM
Exon count:
25
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8827068..8931896, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4652790..4757618, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Iron-sulfur cluster assembly enzyme Neighboring gene transfer RNA:Arginine-TCG 2-3 Neighboring gene transfer RNA:Arginine-TCG 2-4 Neighboring gene antisense RNA:CR44020 Neighboring gene long non-coding RNA:osk Neighboring gene oskar

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Variation of scutellar bristles in Drosophila xvi. Major and minor genes. Fraser A. Genetics, 1970 Jun. PMID 17248499, Free PMC Article
  2. Cooperative phosphoinositide and peptide binding by PSD-95/discs large/ZO-1 (PDZ) domain of polychaetoid, Drosophila zonulin. Ivarsson Y, et al. J Biol Chem, 2011 Dec 30. PMID 22033935, Free PMC Article
  3. Localization of the Drosophila MAGUK protein Polychaetoid is controlled by alternative splicing. Wei X, et al. Mech Dev, 2001 Feb. PMID 11165479
  4. Studies on the Interaction of Mutations Affecting the Chaetae of Drosophila Melanogaster. II. the Relation of Character Expression to Size in Flies Homozygous for Polychaetoid, Hairy, Hairy Wing, and the Combinations of These Factors. Neel JV. Genetics, 1943 Jan. PMID 17247070, Free PMC Article
  5. Variation of scutellar bristles in Drosophila. XIV. Effects of temperature and crowding. Fraser AS, et al. Aust J Biol Sci, 1968 Feb. PMID 5643268

See all (190) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins.
    Title: Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins.
  2. The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila.
    Title: The ZO-1 protein Polychaetoid as an upstream regulator of the Hippo pathway in Drosophila.
  3. Here, we show that a specific isoform of Polychaetoid/ZO-1, Pyd-P, is essential for Drosophila SDs, since, in pyd mutants devoid of Pyd-P, SDs do not form and the SD component Dumbfounded accumulates at ectopic septate-like junctions between abnormally aggregated nephrocytes
    Title: A specific isoform of Pyd/ZO-1 mediates junctional remodeling and formation of slit diaphragms.
  4. Canoe and Polychaetoid stabilize Bazooka/Par3 at cell-cell junctions, helping maintain balanced apical contractility and tissue integrity.
    Title: The Drosophila Afadin and ZO-1 homologues Canoe and Polychaetoid act in parallel to maintain epithelial integrity when challenged by adherens junction remodeling.
  5. Cooperative phosphoinositide and peptide binding by PSD-95/discs large/ZO-1 (PDZ) domain of polychaetoid, Drosophila zonulin.
    Title: Cooperative phosphoinositide and peptide binding by PSD-95/discs large/ZO-1 (PDZ) domain of polychaetoid, Drosophila zonulin.
  6. Most embryos lacking Pyd die with striking defects in morphogenesis of embryonic epithelia including the epidermis, segmental grooves, and tracheal system
    Title: The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled.
  7. A core antagonistic interaction between Pyd and the WW domain E3 ubiquitin ligase Su(dx), was identified.
    Title: Su(dx) E3 ubiquitin ligase-dependent and -independent functions of polychaetoid, the Drosophila ZO-1 homologue.
  8. Results suggest that polychaetoid modulates adherens junction strength and Roughest-mediated preferential cell adhesion.
    Title: Polychaetoid controls patterning by modulating adhesion in the Drosophila pupal retina.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c8896023-8894928 mobile_element_type = transposon:1360{}1270

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in R8 cell development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in branch fusion, open tracheal system HMP PubMed 
involved_in branch fusion, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-cell junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chaeta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fusion cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in head involution IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nephrocyte diaphragm assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hippo signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein localization to cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell adhesion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of embryonic cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nephrocyte diaphragm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
polychaetoid
Names
CG43140-PA
CG43140-PB
CG43140-PC
CG43140-PF
CG43140-PG
CG43140-PI
CG43140-PJ
CG43140-PK
CG43140-PL
CG43140-PM
CG43140-PO
CG43140-PP
extra verticals
failed fusions
pyd-PA
pyd-PB
pyd-PC
pyd-PF
pyd-PG
pyd-PI
pyd-PJ
pyd-PK
pyd-PL
pyd-PM
pyd-PO
pyd-PP
tamou

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    8827068..8931896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260069.2 → NP_001246998.1  polychaetoid, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246998.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6Y7
    Conserved Domains (4) summary
    cd11859
    Location:729 → 790
    SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins
    smart00072
    Location:831 → 1007
    GuKc; Guanylate kinase homologues
    cd00992
    Location:249 → 334
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00791
    Location:2263 → 2351
    ZU5; ZU5 domain

  2. NM_057349.7 → NP_476697.3  polychaetoid, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476697.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q94880, Q9VHK4
    Related
    FBpp0293838
    Conserved Domains (3) summary
    cd11859
    Location:502 → 563
    SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins
    smart00072
    Location:604 → 780
    GuKc; Guanylate kinase homologues
    cd00992
    Location:22 → 107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  3. NM_170646.6 → NP_731293.3  polychaetoid, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731293.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960N4, Q9VHK1
    Conserved Domains (3) summary
    cd11859
    Location:866 → 927
    SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins
    smart00072
    Location:968 → 1144
    GuKc; Guanylate kinase homologues
    cd00992
    Location:386 → 471
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  4. NM_001144556.2 → NP_001138028.1  polychaetoid, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138028.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0U1, Q94880
    Conserved Domains (3) summary
    cd11859
    Location:517 → 578
    SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins
    smart00072
    Location:619 → 795
    GuKc; Guanylate kinase homologues
    cd00992
    Location:37 → 122
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  5. NM_169246.3 → NP_731292.2  polychaetoid, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731292.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8INQ0, Q94880
    Related
    FBpp0293839
    Conserved Domains (3) summary
    cd11859
    Location:502 → 563
    SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins
    smart00072
    Location:604 → 780
    GuKc; Guanylate kinase homologues
    cd00992
    Location:22 → 107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  6. NM_169245.3 → NP_731291.2  polychaetoid, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731291.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VHK3
    Related
    FBpp0293840
    Conserved Domains (4) summary
    cd11859
    Location:502 → 563
    SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins
    smart00072
    Location:604 → 780
    GuKc; Guanylate kinase homologues
    cd00992
    Location:22 → 107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00791
    Location:1958 → 2046
    ZU5; ZU5 domain

  7. NM_001104241.2 → NP_001097711.1  polychaetoid, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097711.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JQV7, Q94880
    Conserved Domains (3) summary
    cd11859
    Location:502 → 563
    SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins
    smart00072
    Location:604 → 780
    GuKc; Guanylate kinase homologues
    cd00992
    Location:22 → 107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  8. NM_001260072.2 → NP_001247001.1  polychaetoid, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247001.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JQV7, Q94880
    Conserved Domains (3) summary
    cd11859
    Location:502 → 563
    SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins
    smart00072
    Location:604 → 780
    GuKc; Guanylate kinase homologues
    cd00992
    Location:22 → 107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  9. NM_176426.4 → NP_788603.1  polychaetoid, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788603.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8INQ1, Q8MQQ3, Q94880
    Related
    FBpp0293837
    Conserved Domains (3) summary
    cd11859
    Location:502 → 563
    SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins
    smart00072
    Location:604 → 780
    GuKc; Guanylate kinase homologues
    cd00992
    Location:22 → 107
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  10. NM_001260071.2 → NP_001247000.1  polychaetoid, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247000.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6C7, G4LU41
    Conserved Domains (3) summary
    cd11859
    Location:624 → 685
    SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins
    smart00072
    Location:726 → 902
    GuKc; Guanylate kinase homologues
    cd00992
    Location:144 → 229
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  11. NM_001104242.3 → NP_001097712.1  polychaetoid, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097712.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JQV8
    Conserved Domains (3) summary
    cd11859
    Location:785 → 846
    SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins
    smart00072
    Location:887 → 1063
    GuKc; Guanylate kinase homologues
    cd00992
    Location:305 → 390
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  12. NM_001382097.1 → NP_001368959.1  polychaetoid, isoform P [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6F7U5U6, G4LU41
    Conserved Domains (3) summary
    cd11859
    Location:729 → 790
    SH3_ZO; Src homology 3 domain of the Tight junction proteins, Zonula occludens (ZO) proteins
    smart00072
    Location:831 → 1007
    GuKc; Guanylate kinase homologues
    cd00992
    Location:249 → 334
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K6C7 A0A0B4K6C7
A0A0B4K6Y7 A0A0B4K6Y7
A0A6F7U5U6 A0A6F7U5U6
A8JQV7 A8JQV7
A8JQV8 A8JQV8
B7Z0U1 B7Z0U1
Q7K4E2 Q7K4E2
Q8INQ0 Q8INQ0
Q8MQQ3 Q8MQQ3
Q94880 Q94880
Q95RX8 Q95RX8
Q9VHK1 Q9VHK1
Q9VHK3 Q9VHK3
Q9VHK4 Q9VHK4

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