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p pink [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41025, updated on 4-Jan-2025

Summary

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Official Symbol
pprovided by FlyBase
Official Full Name
pinkprovided by FlyBase
Primary source
FLYBASE:FBgn0086679
Locus tag
Dmel_CG9770
See related
AllianceGenome:FB:FBgn0086679
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9770; dHPS5; Dmel\CG9770; HPS5; NP_649810; snb
Summary
Involved in compound eye pigmentation; ommochrome biosynthetic process; and protein targeting to lysosome. Located in cytoplasm. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome and Hermansky-Pudlak syndrome 5. Orthologous to human HPS5 (HPS5 biogenesis of lysosomal organelles complex 2 subunit 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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Location:
85A5-85A5; 3-48 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8660903..8670684, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4486625..4489621, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Sys1 golgi trafficking protein Neighboring gene uncharacterized protein Neighboring gene belle Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Tyrosine-GTA 1-6 Neighboring gene transfer RNA:Tyrosine-GTA 1-7 Neighboring gene transfer RNA:Tyrosine-GTA 1-8 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L19 Neighboring gene Unc50 RNA binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic damage at specific gene loci in Drosophila with betatron X-rays. Alexander ML. Genetics, 1975 Nov. PMID 812774, Free PMC Article
  2. Genetic Studies on DROSOPHILA SIMULANS. III. Autosomal Genes. General Discussion. Sturtevant AH. Genetics, 1921 Mar. PMID 17245963, Free PMC Article
  3. Genetic and developmental relationships between two alkaline phosphatases in Drosophilia melanogaster. Wallis BB, et al. Biochem Genet, 1968 Sep. PMID 5717078
  4. Mutation in a testis-specific beta-tubulin in Drosophila: analysis of its effects on meiosis and map location of the gene. Kemphues KJ, et al. Cell, 1980 Sep. PMID 6773669
  5. Interacting proteins identified by genetic interactions: a missense mutation in alpha-tubulin fails to complement alleles of the testis-specific beta-tubulin gene of Drosophila melanogaster. Hays TS, et al. Mol Cell Biol, 1989 Mar. PMID 2498648, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in compound eye pigmentation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in compound eye pigmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in developmental pigmentation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in eye pigment biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ommochrome biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to lysosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of BLOC-2 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
pink
Names
CG9770-PA
CG9770-PB
CG9770-PC
drosophila Hermansky-Pudlak syndrome 5 subunit
p-PA
p-PB
p-PC
pink-peach
sunburst

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    8660903..8670684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316526.1 → NP_001303455.1  pink, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SXI1, Q9VHN9
    UniProtKB/TrEMBL
    U3PV63
    Conserved Domains (3) summary
    COG2319
    Location:17 → 132
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:25 → 63
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:21 → 128
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001316527.1 → NP_001303456.1  pink, isoform C [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SXI1, Q9VHN9
    UniProtKB/TrEMBL
    U3PV63
    Conserved Domains (3) summary
    COG2319
    Location:17 → 132
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:25 → 63
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:21 → 128
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_141553.3 → NP_649810.1  pink, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649810.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8SXI1, Q9VHN9
    UniProtKB/TrEMBL
    U3PV63
    Related
    FBpp0081373
    Conserved Domains (3) summary
    COG2319
    Location:17 → 132
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:25 → 63
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:21 → 128
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VHN9.1 Q9VHN9
U3PV63 U3PV63

Gene LinkOut

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