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COX7AL Cytochrome c oxidase subunit 7A-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40995, updated on 4-Jan-2025

Summary

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Official Symbol
COX7ALprovided by FlyBase
Official Full Name
Cytochrome c oxidase subunit 7A-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0037579
Locus tag
Dmel_CG18193
See related
AllianceGenome:FB:FBgn0037579
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18193; COXJ; COXK; Dmel\CG18193; VIIa
Summary
Predicted to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Is expressed in adult head and spermatozoon. Orthologous to several human genes including COX7A1 (cytochrome c oxidase subunit 7A1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See COX7AL in Genome Data Viewer
Location:
84F13-84F13; 3-48 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8343669..8344310)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4169391..4170032)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Cytochrome c oxidase subunit 7A Neighboring gene ADP ribosylation factor-like 2 Neighboring gene Polynucleotide kinase 3'-phosphatase Neighboring gene Dipeptidyl aminopeptidase III Neighboring gene uncharacterized protein Neighboring gene mir-9380 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Variation in Mitochondria-Derived Transcript Levels Associated With DDT Resistance in the 91-R Strain of Drosophila melanogaster (Diptera: Drosophilidae). Steele LD, et al. J Insect Sci, 2018 Nov 1. PMID 30383265, Free PMC Article
  2. CG7630 is the Drosophila melanogaster homolog of the cytochrome c oxidase subunit COX7B. Brischigliaro M, et al. EMBO Rep, 2022 Aug 3. PMID 35699132, Free PMC Article
  3. The cyclope gene of Drosophila encodes a cytochrome c oxidase subunit VIc homolog. Szuplewski S, et al. Genetics, 2001 Aug. PMID 11514451, Free PMC Article
  4. Analyses of nuclearly encoded mitochondrial genes suggest gene duplication as a mechanism for resolving intralocus sexually antagonistic conflict in Drosophila. Gallach M, et al. Genome Biol Evol, 2010. PMID 21037198, Free PMC Article
  5. Identification of sphingolipid metabolites that induce obesity via misregulation of appetite, caloric intake and fat storage in Drosophila. Walls SM Jr, et al. PLoS Genet, 2013. PMID 24339790, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respirasome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of oxidative phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of respiratory chain complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex IV ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit 7A-like
Names
CG18193-PA
COX7AL-PA
cytochrome c oxidase polypeptide VIIa

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    8343669..8344310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141536.3 → NP_649793.1  cytochrome c oxidase subunit 7A-like [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649793.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VHR9
    Related
    FBpp0081329
    Conserved Domains (1) summary
    cd00928
    Location:51 → 105
    Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VHR9 Q9VHR9

Gene LinkOut

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