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mtg mind the gap [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40970, updated on 4-Jan-2025

Summary

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Official Symbol
mtgprovided by FlyBase
Official Full Name
mind the gapprovided by FlyBase
Primary source
FLYBASE:FBgn0260386
Locus tag
Dmel_CG7549
See related
AllianceGenome:FB:FBgn0260386
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0849/10; CG7549; Dmel\CG7549; l(3)S084910; l(3)S084910b; Mtg; MTG
Summary
Enables carbohydrate derivative binding activity. Involved in synapse assembly. Located in extracellular space; synaptic cleft; and terminal bouton. Is expressed in several structures, including embryonic anal pad; embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; and gut section. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See mtg in Genome Data Viewer
Location:
84F6-84F6; 3-48 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8250497..8260718)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4076219..4086440)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene Replication protein A1 Neighboring gene Minichromosome maintenance 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure-function analysis of endogenous lectin mind-the-gap in synaptogenesis. Rushton E, et al. Dev Neurobiol, 2012 Aug. PMID 22234957, Free PMC Article
  2. The role of protein N-glycosylation in neural transmission. Scott H, et al. Glycobiology, 2014 May. PMID 24643084, Free PMC Article
  3. Presynaptic secretion of mind-the-gap organizes the synaptic extracellular matrix-integrin interface and postsynaptic environments. Rushton E, et al. Dev Dyn, 2009 Mar. PMID 19235718, Free PMC Article
  4. Tenectin recruits integrin to stabilize bouton architecture and regulate vesicle release at the Drosophila neuromuscular junction. Wang Q, et al. Elife, 2018 Jun 14. PMID 29901439, Free PMC Article
  5. Involvement of mind the gap in the organization of the tracheal apical extracellular matrix in Drosophila and Nilaparvata lugens. Yue XZ, et al. Insect Sci, 2020 Aug. PMID 31240817

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Involvement of mind the gap in the organization of the tracheal apical extracellular matrix in Drosophila and Nilaparvata lugens.
    Title: Involvement of mind the gap in the organization of the tracheal apical extracellular matrix in Drosophila and Nilaparvata lugens.
  2. Mind-the-gap lectin plays a role in the regulation of neuromuscular junction embryonic synaptogenesis.
    Title: Structure-function analysis of endogenous lectin mind-the-gap in synaptogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables carbohydrate derivative binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chitin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic cleft IDA
Inferred from Direct Assay
more info
 PubMed 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mind the gap
Names
CG7549-PE
CG7549-PF
CG7549-PG
CG7549-PH
Mind-the-Gap
lethal (3) S084910b
mtg-PE
mtg-PF
mtg-PG
mtg-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    8250497..8260718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141518.4 → NP_649775.2  mind the gap, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649775.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0C4DHA4
    Conserved Domains (1) summary
    pfam01607
    Location:368 → 418
    CBM_14; Chitin binding Peritrophin-A domain

  2. NM_001043221.4 → NP_001036686.3  mind the gap, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036686.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5X0L7, F3YDJ7, Q0KIA5
    Conserved Domains (1) summary
    pfam01607
    Location:240 → 290
    CBM_14; Chitin binding Peritrophin-A domain

  3. NM_001300302.1 → NP_001287231.1  mind the gap, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287231.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5X0L7, F3YDJ7, Q0KIA5
    Conserved Domains (1) summary
    pfam01607
    Location:240 → 290
    CBM_14; Chitin binding Peritrophin-A domain

  4. NM_169212.3 → NP_731221.2  mind the gap, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731221.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0C4DHF5
    Conserved Domains (1) summary
    pfam01607
    Location:409 → 459
    CBM_14; Chitin binding Peritrophin-A domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0C4DHA4 A0A0C4DHA4
A0A0C4DHF5 A0A0C4DHF5
Q0KIA5 Q0KIA5
Q95U23 Q95U23

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