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PolI DNA polymerase iota [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40965, updated on 4-Jan-2025

Summary

Official Symbol
PolIprovided by FlyBase
Official Full Name
DNA polymerase iotaprovided by FlyBase
Primary source
FLYBASE:FBgn0037554
Locus tag
Dmel_CG7602
See related
AllianceGenome:FB:FBgn0037554
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AAF54198; CG7602; Dm-Poliota; Dmel\CG7602; DNA Pol II-iota; DNA-pol iota; DNApol-i; DNApol-iota; drad30B; Poliota
Summary
Enables DNA-directed DNA polymerase activity. Involved in translesion synthesis. Is expressed in organism. Orthologous to human POLI (DNA polymerase iota). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See PolI in Genome Data Viewer
Location:
84F4-84F5; 3-48 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8233507..8237389)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4059229..4063111)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45551 Neighboring gene long non-coding RNA:CR45550 Neighboring gene antisense RNA:CR45549 Neighboring gene transcriptional Adaptor 2b Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-directed DNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-directed DNA polymerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables damaged DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in translesion synthesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in translesion synthesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
DNA polymerase iota
Names
CG7602-PA
CG7602-PB
CG7602-PC
DNApol-iota
PolI-PA
PolI-PB
PolI-PC
NP_001287227.1
NP_649772.1
NP_731214.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    8233507..8237389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169207.2NP_731214.1  DNA polymerase iota, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731214.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VHV1
    Related
    FBpp0081293
    Conserved Domains (1) summary
    cd01703
    Location:18411
    PolY_Pol_iota; DNA Polymerase iota
  2. NM_141515.3NP_649772.1  DNA polymerase iota, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649772.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VHV1
    Related
    FBpp0081294
    Conserved Domains (1) summary
    cd01703
    Location:18411
    PolY_Pol_iota; DNA Polymerase iota
  3. NM_001300298.1NP_001287227.1  DNA polymerase iota, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287227.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VHV1
    Conserved Domains (1) summary
    cd01703
    Location:18411
    PolY_Pol_iota; DNA Polymerase iota