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EMC1 ER membrane protein complex subunit 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40933, updated on 9-Dec-2024

Summary

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Official Symbol
EMC1provided by FlyBase
Official Full Name
ER membrane protein complex subunit 1provided by FlyBase
Primary source
FLYBASE:FBgn0037530
Locus tag
Dmel_CG2943
See related
AllianceGenome:FB:FBgn0037530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2943; Dmel\CG2943; emc1; NEST:bs09f06
Summary
Contributes to membrane insertase activity. Involved in tail-anchored membrane protein insertion into ER membrane. Located in endomembrane system. Is expressed in adult head; adult midgut enterocyte; enteroblast; and enteroendocrine cell. Used to study cerebellar atrophy, visual impairment, and psychomotor retardation and intestinal cancer. Human ortholog(s) of this gene implicated in cerebellar atrophy, visual impairment, and psychomotor retardation. Orthologous to human EMC1 (ER membrane protein complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See EMC1 in Genome Data Viewer
Location:
84E4-84E5; 3-48 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7903030..7907363, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3728752..3733085, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Arginyl-tRNA synthetase, mitochondrial Neighboring gene mitochondrial ribosomal protein S9 Neighboring gene water witch Neighboring gene TBP-associated factor 7 Neighboring gene Phosphoribosylamidotransferase Neighboring gene Riboflavin kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De novo variants in EMC1 lead to neurodevelopmental delay and cerebellar degeneration and affect glial function in Drosophila. Chung HL, et al. Hum Mol Genet, 2022 Sep 29. PMID 35234901, Free PMC Article
  2. Exploiting fly models to investigate rare human neurological disorders. Tanaka T, et al. Neural Regen Res, 2025 Jan 1. PMID 38767473, Free PMC Article
  3. An EMC-Hpo-Yki axis maintains intestinal homeostasis under physiological and pathological conditions. Shi L, et al. Development, 2023 Dec 15. PMID 38031990
  4. ER complex proteins are required for rhodopsin biosynthesis and photoreceptor survival in Drosophila and mice. Xiong L, et al. Cell Death Differ, 2020 Feb. PMID 31263175, Free PMC Article
  5. dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors. Satoh T, et al. Elife, 2015 Feb 26. PMID 25715730, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to membrane insertase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in tail-anchored membrane protein insertion into ER membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of EMC complex IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system HDA PubMed 

General protein information

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Preferred Names
ER membrane protein complex subunit 1
Names
CG2943-PA
CG2943-PB
CG2943-PC
CG2943-PD
EMC1-PA
EMC1-PB
EMC1-PC
EMC1-PD
ER membrane protein complex 1
endoplasmic reticulum membrane protein complex 1
subunit 1 of EMC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7903030..7907363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300287.1 → NP_001287216.1  ER membrane protein complex subunit 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287216.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGV1
    Conserved Domains (1) summary
    pfam07774
    Location:702 → 907
    DUF1620; Protein of unknown function (DUF1620)

  2. NM_001300286.1 → NP_001287215.1  ER membrane protein complex subunit 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287215.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VHY6
    Conserved Domains (1) summary
    pfam07774
    Location:709 → 914
    DUF1620; Protein of unknown function (DUF1620)

  3. NM_001300288.1 → NP_001287217.1  ER membrane protein complex subunit 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287217.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGV1
    Conserved Domains (1) summary
    pfam07774
    Location:702 → 907
    DUF1620; Protein of unknown function (DUF1620)

  4. NM_141490.2 → NP_649747.1  ER membrane protein complex subunit 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649747.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VHY6
    Related
    FBpp0081262
    Conserved Domains (1) summary
    pfam07774
    Location:709 → 914
    DUF1620; Protein of unknown function (DUF1620)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGV1 A0A0B4LGV1
Q95TQ6 Q95TQ6
Q9VHY6 Q9VHY6

Gene LinkOut

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