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CG2616 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40915, updated on 4-Jan-2025

Summary

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Official Symbol
CG2616provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037512
Locus tag
Dmel_CG2616
See related
AllianceGenome:FB:FBgn0037512
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG2616
Summary
Predicted to enable glutathione transmembrane transporter activity. Predicted to be involved in glutathione import into mitochondrion. Predicted to be active in mitochondrial inner membrane. Orthologous to several human genes including SLC25A40 (solute carrier family 25 member 40). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG2616 in Genome Data Viewer
Location:
84D13-84D13; 3-48 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7722417..7724715)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3548139..3550437)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Neuroligin 1 Neighboring gene long non-coding RNA:CR44260 Neighboring gene long non-coding RNA:CR44935 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers. Curcio R, et al. Int J Mol Sci, 2020 Aug 22. PMID 32842667, Free PMC Article
  2. Phylogenetic Analysis Guides Transporter Protein Deorphanization: A Case Study of the SLC25 Family of Mitochondrial Metabolite Transporters. Byrne KL, et al. Biomolecules, 2023 Aug 28. PMID 37759714, Free PMC Article
  3. The impact of genome variation and diet on the metabolic phenotype and microbiome composition of Drosophila melanogaster. Jehrke L, et al. Sci Rep, 2018 Apr 18. PMID 29670218, Free PMC Article
  4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
  5. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glutathione transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutathione import into mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG2616-PA
CG2616-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7722417..7724715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300283.1 → NP_001287212.1  uncharacterized protein Dmel_CG2616, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287212.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VI05
    Conserved Domains (1) summary
    pfam00153
    Location:230 → 321
    Mito_carr; Mitochondrial carrier protein

  2. NM_141474.3 → NP_649731.1  uncharacterized protein Dmel_CG2616, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649731.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VI05
    Related
    FBpp0081235
    Conserved Domains (1) summary
    pfam00153
    Location:230 → 321
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VI05 Q9VI05

Gene LinkOut

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