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alpha-Est7 alpha-Esterase-7 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40901, updated on 4-Jan-2025

Summary

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Official Symbol
alpha-Est7provided by FlyBase
Official Full Name
alpha-Esterase-7provided by FlyBase
Primary source
FLYBASE:FBgn0015575
Locus tag
Dmel_CG1112
See related
AllianceGenome:FB:FBgn0015575
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
aE7; ali; Ali; alpha est7; alpha-EST7; Alpha-Est7; alphaE7; alphaest-7; alphaEst7; CG1112; DmalphaE7; Dmel\CG1112; Est-23; Est23; EST23; H; Mce
Summary
Enables carboxylesterase activity. Involved in determination of adult lifespan; lipid storage; and response to organophosphorus. Is expressed in several structures, including adult head; adult heart; embryonic hindgut; embryonic/larval crystal cell; and fat body. Orthologous to human CES3 (carboxylesterase 3) and CES4A (carboxylesterase 4A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See alpha-Est7 in Genome Data Viewer
Location:
84D9-84D9; 3-48 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7519563..7523753, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3345285..3349475, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene alpha-Esterase-8 Neighboring gene Ubiquitin conjugating enzyme 84D Neighboring gene alpha-Esterase-6 Neighboring gene pseudo Neighboring gene Rtnl2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hydrolysis of pyrethroids by carboxylesterases from Lucilia cuprina and Drosophila melanogaster with active sites modified by in vitro mutagenesis. Heidari R, et al. Insect Biochem Mol Biol, 2005 Jun. PMID 15857765
  2. A cluster of esterase genes on chromosome 3R of Drosophila melanogaster includes homologues of esterase genes conferring insecticide resistance in Lucilia cuprina. Spackman ME, et al. Biochem Genet, 1994 Feb. PMID 8031294
  3. Biochemical and physiological studies of soluble esterases from Drosophila melanogaster. Healy MJ, et al. Biochem Genet, 1991 Aug. PMID 1747098
  4. Integrating circadian activity and gene expression profiles to predict chronotoxicity of Drosophila suzukii response to insecticides. Hamby KA, et al. PLoS One, 2013. PMID 23861907, Free PMC Article
  5. Circadian clock regulates response to pesticides in Drosophila via conserved Pdp1 pathway. Beaver LM, et al. Toxicol Sci, 2010 Jun. PMID 20348229, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. alpha-Est7 gene is not essential for Drosophila development but serves important functions for insecticide tolerance, lipid metabolism and lifespan control.
    Title: Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster α-Esterase-7.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables carboxylesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carboxylesterase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables serine hydrolase activity HDA PubMed 
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to organophosphorus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
alpha-Esterase-7
Names
CG1112-PA
aliesterase
aliesteraseless
alpha-Est7-PA
carboxylesterase 23
esterase 23
fragment H
malathion carboxylesterase
NP_524261.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7519563..7523753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079537.4 → NP_524261.1  alpha-Esterase-7 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524261.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24201, Q9VIB5
    Related
    FBpp0081074
    Conserved Domains (2) summary
    COG0657
    Location:116 → 221
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:27 → 514
    COesterase; Carboxylesterase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24201 Q24201
Q8IH63 Q8IH63
Q9VIB5 Q9VIB5

Gene LinkOut

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