Mics1 Mitochondrial morphology and cristae structure 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mics1provided by FlyBase
Official Full Name: Mitochondrial morphology and cristae structure 1provided by FlyBase
Primary source: FLYBASE:FBgn0037506
Locus tag: Dmel_CG1287
See related: AllianceGenome:FB:FBgn0037506
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BEST:GH03396; CG1287; Dmel\CG1287; dMICS1
Summary: Predicted to enable calcium channel activity. Predicted to be involved in calcium export from the mitochondrion; inner mitochondrial membrane organization; and negative regulation of release of cytochrome c from mitochondria. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head. Orthologous to human GHITM (growth hormone inducible transmembrane protein). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (7500951..7502376, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (3326673..3328098, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in calcium export from the mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in inner mitochondrial membrane organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in inner mitochondrial membrane organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of release of cytochrome c from mitochondria	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of positive regulation of mitochondrial ATP synthesis coupled electron transport	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in organelle membrane	ISM Inferred from Sequence Model more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain