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alpha-Est9 alpha-Esterase-9 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40897, updated on 4-Jan-2025

Summary

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Official Symbol
alpha-Est9provided by FlyBase
Official Full Name
alpha-Esterase-9provided by FlyBase
Primary source
FLYBASE:FBgn0015577
Locus tag
Dmel_CG1128
See related
AllianceGenome:FB:FBgn0015577
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
aE9; alphaE9; CG1128; DmalphaE9; Dmel\CG1128; Dm_3R:18691; Est9; J
Summary
Predicted to enable carboxylesterase activity. Is expressed in organism. Orthologous to human CES2 (carboxylesterase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See alpha-Est9 in Genome Data Viewer
Location:
84D9-84D9; 3-48 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7493921..7505098, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3319643..3330820, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Valine-CAC 2-4 Neighboring gene alpha-Esterase-10 Neighboring gene uncharacterized protein Neighboring gene Mitochondrial morphology and cristae structure 1 Neighboring gene alpha-Esterase-8 Neighboring gene Ubiquitin conjugating enzyme 84D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A cluster of esterase genes on chromosome 3R of Drosophila melanogaster includes homologues of esterase genes conferring insecticide resistance in Lucilia cuprina. Spackman ME, et al. Biochem Genet, 1994 Feb. PMID 8031294
  2. Carboxyl/cholinesterases: a case study of the evolution of a successful multigene family. Oakeshott JG, et al. Bioessays, 1999 Dec. PMID 10580988
  3. Molecular cloning of an alpha-esterase gene cluster on chromosome 3r of Drosophila melanogaster. Russell RJ, et al. Insect Biochem Mol Biol, 1996 Mar. PMID 8900595
  4. Developmental expression and gene/enzyme identifications in the alpha esterase gene cluster of Drosophila melanogaster. Campbell PM, et al. Insect Mol Biol, 2003 Oct. PMID 12974951
  5. Duplication and divergence of the genes of the alpha-esterase cluster of Drosophila melanogaster. Robin C, et al. J Mol Evol, 1996 Sep. PMID 8703090

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables carboxylesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables cholinesterase activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
  

General protein information

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Preferred Names
alpha-Esterase-9
Names
CG1128-PC
CG1128-PD
alpha-Est9-PC
alpha-Est9-PD
fragment J
NP_524258.2
NP_731165.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7493921..7505098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169187.3 → NP_731165.2  alpha-Esterase-9, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731165.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24203, Q9VIB1
    Conserved Domains (2) summary
    COG0657
    Location:115 → 237
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:33 → 555
    COesterase; Carboxylesterase family

  2. NM_079534.3 → NP_524258.2  alpha-Esterase-9, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524258.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q1RKR1, Q9VIB0
    Conserved Domains (2) summary
    COG0657
    Location:115 → 219
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:33 → 537
    COesterase; Carboxylesterase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24203 Q24203
Q9VIB0 Q9VIB0
Q9VIB1 Q9VIB1

Gene LinkOut

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