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gfzf GST-containing FLYWCH zinc-finger protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40858, updated on 9-Dec-2024

Summary

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Official Symbol
gfzfprovided by FlyBase
Official Full Name
GST-containing FLYWCH zinc-finger proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0250732
Locus tag
Dmel_CG33546
See related
AllianceGenome:FB:FBgn0250732
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg10065; CG10065; CG31329; CG31492; CG33546; dGFZF; Dmel\CG33546; Gfzf; GFZF; l(3)84Cc; Su(Kpn)
Summary
Enables DNA-binding transcription factor binding activity; glutathione binding activity; and glutathione transferase activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytoplasm. Is active in nucleus. Colocalizes with euchromatin. Is expressed in amnioserosa; embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See gfzf in Genome Data Viewer
Location:
84C6-84C6; 3-48 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7145880..7150968, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2971602..2976690, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene 48 related 1 Neighboring gene antisense RNA:CR42738 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Spindle assembly abnormal 4 Neighboring gene MAGE

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An essential cell cycle regulation gene causes hybrid inviability in Drosophila. Phadnis N, et al. Science, 2015 Dec 18. PMID 26680200, Free PMC Article
  2. Identification and characterization of a novel Drosophila melanogaster glutathione S-transferase-containing FLYWCH zinc finger protein. Dai MS, et al. Gene, 2004 Nov 10. PMID 15527965
  3. Altered Localization of Hybrid Incompatibility Proteins in Drosophila. Cooper JC, et al. Mol Biol Evol, 2019 Aug 1. PMID 31038678, Free PMC Article
  4. Functionally distinct promoter classes initiate transcription via different mechanisms reflected in focused versus dispersed initiation patterns. Serebreni L, et al. EMBO J, 2023 May 15. PMID 37013908, Free PMC Article
  5. Speciation and changes in male gene expression in Drosophila. Patlar B, et al. Genome, 2021 Feb. PMID 32730707

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. localization at telomeres significantly different between D. simulans and D. melanogaster, reflecting the rapid evolution of telomeric retrotransposon copy number composition between the two species
    Title: Altered Localization of Hybrid Incompatibility Proteins in Drosophila.
  2. Gfzf functioned epistatically with the thioredoxin peroxidase Jafrac1 and the thioredoxin reductase 1 TrxR-1 to regulate mitochondrial dynamics
    Title: Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation.
  3. GFZF is the first transcriptional coactivator with intrinsic GST activity, and its identification as a transcriptional coactivator provides an explanation for its role in numerous biological processes.
    Title: GFZF, a Glutathione S-Transferase Protein Implicated in Cell Cycle Regulation and Hybrid Inviability, Is a Transcriptional Coactivator.
  4. GST-containing FLYWCH zinc-finger protein localizes to the cytoplasm of fly cells and is expressed through all stages of fly embryonic development.
    Title: Identification and characterization of a novel Drosophila melanogaster glutathione S-transferase-containing FLYWCH zinc finger protein.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables glutathione binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
GST-containing FLYWCH zinc-finger protein
Names
CG33546-PB
CG33546-PD
CG33546-PE
gfzf-PB
gfzf-PD
gfzf-PE
lethal (3) 84Cc
suppressor of killer of prune
NP_001014609.2
NP_001014610.1
NP_001262335.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7145880..7150968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014610.2 → NP_001014610.1  GST-containing FLYWCH zinc-finger protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014610.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NP69, Q9VI71
    Conserved Domains (4) summary
    cd03177
    Location:900 → 1017
    GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
    COG0625
    Location:812 → 1000
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    pfam04500
    Location:597 → 663
    FLYWCH; FLYWCH zinc finger domain
    cl00388
    Location:811 → 886
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  2. NM_001014609.3 → NP_001014609.2  GST-containing FLYWCH zinc-finger protein, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014609.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NL74, Q8INS9
    Conserved Domains (3) summary
    cd03177
    Location:89 → 206
    GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
    COG0625
    Location:1 → 189
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cl00388
    Location:1 → 75
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  3. NM_001275406.1 → NP_001262335.1  GST-containing FLYWCH zinc-finger protein, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262335.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NP69, Q9VI71
    Conserved Domains (4) summary
    cd03177
    Location:900 → 1017
    GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
    COG0625
    Location:812 → 1000
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    pfam04500
    Location:597 → 663
    FLYWCH; FLYWCH zinc finger domain
    cl00388
    Location:811 → 886
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NP69 Q6NP69
Q8INS9 Q8INS9

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