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Dpck Dephospho-CoA kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40846, updated on 9-Dec-2024

Summary

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Official Symbol
Dpckprovided by FlyBase
Official Full Name
Dephospho-CoA kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0037469
Locus tag
Dmel_CG1939
See related
AllianceGenome:FB:FBgn0037469
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1939; dDPCK; Dmel\CG1939; DPCK
Summary
Predicted to enable dephospho-CoA kinase activity. Predicted to be involved in coenzyme A biosynthetic process. Located in endomembrane system. Is expressed in adult head and organism. Orthologous to human DCAKD (dephospho-CoA kinase domain containing). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Dpck in Genome Data Viewer
Location:
84B2-84B2; 3-48 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7082182..7083251)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2907904..2908973)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45908 Neighboring gene uncharacterized protein Neighboring gene RNA and export factor binding protein 1 Neighboring gene tailor Neighboring gene antisense RNA:CR45907 Neighboring gene alpha-Tubulin at 84B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system. Bosveld F, et al. Hum Mol Genet, 2008 Jul 1. PMID 18407920
  2. EMC is required for biogenesis of Xport-A, an essential chaperone of Rhodopsin-1 and the TRP channel. Gaspar CJ, et al. EMBO Rep, 2022 Jan 5. PMID 34918864, Free PMC Article
  3. Isolation of gene sets affected specifically by polyglutamine expression: implication of the TOR signaling pathway in neurodegeneration. Nelson B, et al. Cell Death Differ, 2005 Aug. PMID 15861189
  4. A Genetic Screen Using the Drosophila melanogaster TRiP RNAi Collection To Identify Metabolic Enzymes Required for Eye Development. Pletcher RC, et al. G3 (Bethesda), 2019 Jul 9. PMID 31036678, Free PMC Article
  5. Functional requirements of protein kinases and phosphatases in the development of the Drosophila melanogaster wing. Ostalé CM, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599799, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables dephospho-CoA kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dephospho-CoA kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables dephospho-CoA kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in coenzyme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in coenzyme A biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
located_in extrinsic component of mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Dephospho-CoA kinase
Names
CG1939-PA
Dpck-PA
NP_649692.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7082182..7083251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141435.3 → NP_649692.2  Dephospho-CoA kinase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649692.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SWY7, Q9VI57
    Related
    FBpp0081152
    Conserved Domains (1) summary
    cd02022
    Location:3 → 184
    DPCK; Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SWY7 Q8SWY7
Q9VI57 Q9VI57

Gene LinkOut

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