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zen2 zerknullt-related [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40827, updated on 9-Dec-2024

Summary

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Official Symbol
zen2provided by FlyBase
Official Full Name
zerknullt-relatedprovided by FlyBase
Primary source
FLYBASE:FBgn0004054
Locus tag
Dmel_CG1048
See related
AllianceGenome:FB:FBgn0004054
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG:DS00276.10; CG1048; Dmel\CG1048; z2; zpr
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including amnioserosa; amnioserosa anlage; dorsal ectoderm; dorsal ectoderm anlage; and dorsal fold. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See zen2 in Genome Data Viewer
Location:
84A5-84A5; 3-48 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6743135..6744136, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2568857..2569858, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ccp84Aa Neighboring gene proboscipedia Neighboring gene uncharacterized protein Neighboring gene zerknullt

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The proboscipedia locus of the Antennapedia complex: a molecular and genetic analysis. Pultz MA, et al. Genes Dev, 1988 Jul. PMID 2850265
  2. Molecular characterization of the zerknüllt region of the Antennapedia gene complex in Drosophila. Rushlow C, et al. Genes Dev, 1987 Dec. PMID 2892759
  3. Maternal regulation of zerknüllt: a homoeobox gene controlling differentiation of dorsal tissues in Drosophila. Rushlow C, et al. Nature, 1987 Dec 10-16. PMID 2891036
  4. Class 3 Hox genes in insects and the origin of zen. Falciani F, et al. Proc Natl Acad Sci U S A, 1996 Aug 6. PMID 8710895, Free PMC Article
  5. Ectopic expression of the Drosophila homeotic gene proboscipedia under Antennapedia P1 control causes dominant thoracic defects. Cribbs DL, et al. Genetics, 1992 Nov. PMID 1361474, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zerknullt-related
Names
CG1048-PA
CG1048-PB
Zerknullt-related
zen-pattern-related
zen2-PA
zen2-PB
zerknullt 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    6743135..6744136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057446.3 → NP_476794.1  zerknullt-related, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476794.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P09090, Q9V3K6
    Related
    FBpp0081171
    Conserved Domains (1) summary
    pfam00046
    Location:46 → 99
    Homeobox; Homeobox domain

  2. NM_001144545.2 → NP_001138017.1  zerknullt-related, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138017.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0IGT0
    Conserved Domains (1) summary
    pfam00046
    Location:26 → 79
    Homeobox; Homeobox domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09090.2 P09090
Q0IGT0 Q0IGT0

Gene LinkOut

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